ArticlePsychopharmacology2021
Aversion-resistant fentanyl self-administration in mice.
Article in Psychopharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 39 citations in OpenAlex.
- Robust effects of food deprivation as a relapse trigger: comparison to other stressors, and investigation of predictive individual traits in male and female rats.Psychopharmacology · 2026Article
- Voluntary oral fentanyl intake produces dose- and sex-dependent physical dependence in mice without overt affective disturbances.bioRxiv : the preprint server for biology · 2026Article
- Fentanyl reinforcement history has sex-specific effects on multi-step decision-making.Neuropharmacology · 2026Article
- Mechanistic and translational insights from preclinical cocaine choice procedures on the economic substitutability of cocaine and nondrug reinforcers.Neuroscience and biobehavioral reviews · 2025Review
- Escalation of intravenous fentanyl self-administration and assessment of withdrawal behavior in male and female mice.Psychopharmacology · 2025Article
- An automated group-housed oral fentanyl self-administration method in mice.Psychopharmacology · 2025Article
- Oral fentanyl consumption and withdrawal impairs fear extinction learning and enhances basolateral amygdala principal neuron excitatory-inhibitory balance in male and female mice.Addiction neuroscience · 2024Article
- Effects of pharmacological and environmental manipulations on choice between fentanyl and shock avoidance/escape in male and female rats under mutually exclusive and non-exclusive choice conditions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Article
- An open-source behavior controller for associative learning and memory (B-CALM).Behavior research methods · 2024Article
- Fentanyl overdose: Temporal effects and prognostic factors in SKH1 mice.Basic & clinical pharmacology & toxicology · 2024Article
- Morphine-context associative memory and locomotor sensitization in mice are modulated by sex and context in a dose-dependent manner.bioRxiv : the preprint server for biology · 2023Article
- Rats have low motivation to self-administer oral methamphetamine across increasing response requirements.Behavioural brain research · 2023Article
- Claustral neurons projecting to frontal cortex restrict opioid consumption.Current biology : CB · 2023Article
- Opioid withdrawal: role in addiction and neural mechanisms.Psychopharmacology · 2023Review
- All Hands on Deck: We Need Multiple Approaches To Uncover the Neuroscience behind the Opioid Overdose Crisis.ACS chemical neuroscience · 2023Review
- IGF-1 Microinjection in the Prefrontal Cortex Attenuates Fentanyl-Seeking Behavior in Mice.The international journal of neuropsychopharmacology · 2023Article
- Extended access to fentanyl vapor self-administration leads to addiction-like behaviors in mice: Blood chemokine/cytokine levels as potential biomarkers.Addiction neuroscience · 2023Article
- Distinctive Neuroanatomic Regions Involved in Cocaine-Induced Behavioral Sensitization in Mice.Biomedicines · 2023Article
- Intravenous fentanyl self-administration in male and female C57BL/6J and DBA/2J mice.Scientific reports · 2023Article
- Crossed high alcohol preferring mice exhibit aversion-resistant responding for alcohol with quinine but not footshock punishment.Alcohol (Fayetteville, N.Y.) · 2022Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
rationaleAnimal models of compulsive drug use that continues despite negative consequences can be used to investigate the neural mechanisms of addiction. However, models of punished or aversion-resistant opioid self-administration are notably lacking.
objectivesWe sought to develop an aversion-resistant, oral fentanyl self-administration paradigm.
methodsIn Experiment 1, C57BL/6J male and female, adult mice consumed fentanyl (10 μg/mL) in a two-bottle drinking in the dark task and escalating concentrations of quinine were added to the bottles. In Experiment 2, mice were trained to administer oral fentanyl (10 μg/mL) in an operant response task. Quinine was next added to the fentanyl solution in escalating concentrations. In Experiment 3, mice were trained to respond for oral fentanyl or fentanyl adulterated with 500 μM quinine on every session. In Experiment 4, mice were trained to respond for a 1% sucrose solution before introduction of quinine.
resultsQuinine reduced two-bottle choice consumption in males but not in females. Both sexes demonstrated the ability to detect the selected concentrations of quinine in fentanyl. In the operant chamber, mice responded robustly for oral fentanyl but introduction of quinine at any stage of training was insufficient to reduce responding. In contrast, quinine reduced responding for sucrose at concentrations above 250 μM.
conclusionsMice will respond for and consume oral fentanyl in both a two-bottle choice and an operant response task. Quinine is detectable in fentanyl but mice will continue to respond for and consume fentanyl with quinine in both paradigms. These data support the use of these models in behavioral studies of compulsive-like opioid use.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.