Evidence map›Paper›PMID 33226341›Full record

ArticleeLife2020

The deubiquitylase Ubp15 couples transcription to mRNA export.

Fanny Eyboulet, Célia Jeronimo, Jacques Côté, François Robert

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Nuclear mRNA export.Acta biochimica et biophysica Sinica · 2024
    Review
  2. Evolution and diversification of the nuclear pore complex.Biochemical Society transactions · 2021
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Fanny EybouletInstitut de recherches cliniques de Montréal, Montréal, Canada.
Célia JeronimoInstitut de recherches cliniques de Montréal, Montréal, Canada.
Jacques CôtéSt-Patrick Research Group in Basic Oncology, Laval University Cancer Research Center, Axe Oncologie du Centre de Recherche du CHU de Québec-Université Laval, Québec City, Canada.ORCID 0000-0001-6751-555X
François RobertInstitut de recherches cliniques de Montréal, Montréal, Canada.ORCID 0000-0003-1054-5920

Funding

CIHR FDN-143314CIHR MOP-162334Natural Sciences and Engineering Research Council of Canada 435833-2013
6 · The paper itself

Abstract

Nuclear export of messenger RNAs (mRNAs) is intimately coupled to their synthesis. pre-mRNAs assemble into dynamic ribonucleoparticles as they are being transcribed, processed, and exported. The role of ubiquitylation in this process is increasingly recognized but, while a few E3 ligases have been shown to regulate nuclear export, evidence for deubiquitylases is currently lacking. Here we identified deubiquitylase Ubp15 as a regulator of nuclear export in

Indexed as

EndopeptidasesGene DeletionGene Expression Regulation, FungalMass SpectrometryNuclear PoreNuclear ProteinsNucleocytoplasmic Transport ProteinsRNA-Binding ProteinsRNA, MessengerRNA Polymerase IISaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTranscription, GeneticEndopeptidasesMEX67 protein, S cerevisiaeNuclear ProteinsNucleocytoplasmic Transport ProteinsRNA-Binding ProteinsRNA, MessengerRNA Polymerase IISaccharomyces cerevisiae ProteinsUbp15 protein, S cerevisiaechromosomesdeubiquitylasegene expressiongeneticsgenomicsMex67nuclear exportRsp5S. cerevisiaetranscriptionUbp15

Identifiers

PMID33226341
PMCPMC7682988

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.