Evidence map›Paper›PMID 33226137›Full record

ArticleThe EMBO journal2020

Receptor-mediated clustering of FIP200 bypasses the role of LC3 lipidation in autophagy.

Amelia E Ohnstad, Jose M Delgado, Brian J North, Isha Nasa, Arminja N Kettenbach, Sebastian W Schultz, Christopher J Shoemaker

Open access · hybridAbstract read
In one paragraph

Article in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 115 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. The Human Autophagy Core Complexes.Annual review of biochemistry · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Review
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  14. Article
  15. The human autophagy-initiating complexes ULK1C and PI3KC3-C1.The Journal of biological chemistry · 2025
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Amelia E OhnstadDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Jose M DelgadoDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Brian J NorthDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.
Isha NasaDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.ORCID 0000-0001-7699-795X
Arminja N KettenbachDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.ORCID 0000-0003-3979-4576
Sebastian W SchultzCentre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Oslo, Norway.
Christopher J ShoemakerDepartment of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, NH, USA.ORCID 0000-0003-2004-6340
Dartmouth College · USOslo University Hospital · NO

Funding

Translational Engineering in Cancer (TEC)P30CA023108 · NCI · DARTMOUTH COLLEGE · PI Steven D Leach · 1985 to 2026
$91.3M
Understanding the role of RNA-binding protein mutations in cancerP20GM113132 · NIGMS · DARTMOUTH COLLEGE · PI MADDEN, DEAN R · 2016 to 2025
$25.9M
Phosphorylation Signaling by Phosphoprotein PhosphatasesR35GM119455 · NIGMS · DARTMOUTH COLLEGE · PI Arminja Nadine Kettenbach · 2016 to 2026
$5.1M
Elucidating the function of mammalian autophagy receptors in selective autophagyR00GM117218 · NIGMS · DARTMOUTH COLLEGE · PI SHOEMAKER, CHRISTOPHER J · 2019 to 2021
$747k
HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM113132NCI NIH HHS P30 CA023108NIGMS NIH HHS P20 GM113132NIGMS NIH HHS R00 GM117218NIGMS NIH HHS R35 GM119455
6 · The paper itself

Abstract

Autophagosome formation requires multiple autophagy-related (ATG) factors. However, we find that a subset of autophagy substrates remains robustly targeted to the lysosome in the absence of several core ATGs, including the LC3 lipidation machinery. To address this unexpected result, we performed genome-wide CRISPR screens identifying genes required for NBR1 flux in ATG7

Indexed as

AutophagosomesAutophagyAutophagy-Related Protein 7Autophagy-Related ProteinsCell DeathCluster AnalysisHEK293 CellsHumansIntracellular Signaling Peptides and ProteinsK562 CellsLysosomesMicrotubule-Associated ProteinsNeoplasm ProteinsProtein Serine-Threonine KinasesUbiquitinATG7 protein, humanAutophagy-Related Protein 7Autophagy-Related ProteinsIntracellular Signaling Peptides and ProteinsMAP1LC3A protein, humanMicrotubule-Associated ProteinsNBR1 protein, humanNeoplasm ProteinsProtein Serine-Threonine KinasesRB1CC1 protein, humanTAX1BP1 protein, humanTBK1 protein, humanUbiquitinATG7autophagosomeNBR1selective autophagyTAX1BP1

Identifiers

PMID33226137
PMCPMC7737610
OpenAlexW3108748336

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.