Evidence map›Paper›PMID 33226131›Full record

ArticleEuropean journal of immunology2021

Broadly reactive human CD4

Antonino Cassotta, Jérémie D Goldstein, Greta Durini, David Jarrossay, Franca Baggi Menozzi, Mario Venditti, Alessandro Russo, Marco Falcone, Antonio Lanzavecchia, Maria Cristina Gagliardi and 2 more

Abstract read
In one paragraph

Article in European journal of immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Immunogenomic landscape of the T cell repertoire after human lung transplantation and its clinical relevance.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2026
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  14. Ceftazidime-Avibactam for the Treatment of Carbapenem-ResistantJournal of clinical and experimental hepatology
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Antonino CassottaInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.ORCID 0000-0001-8674-4294
Jérémie D GoldsteinInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Greta DuriniInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
David JarrossayInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.
Franca Baggi MenozziServizio di Microbiologia EOLAB, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Mario VendittiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Alessandro RussoDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.ORCID 0000-0003-3846-4620
Marco FalconeDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Antonio LanzavecchiaInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.ORCID 0000-0002-3041-7240
Maria Cristina GagliardiCenter for Gender Specific Medicine, Istituto Superiore di Sanità, Rome, Italy.
Daniela LatorreInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.ORCID 0000-0003-1031-1534
Federica SallustoInstitute for Research in Biomedicine, Università della Svizzera italiana, Bellinzona, Switzerland.ORCID 0000-0003-3750-2752

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Enterobacteriaceae are a large family of Gram-negative bacteria that includes both commensals and opportunistic pathogens. The latter can cause severe nosocomial infections, with outbreaks of multi-antibiotics resistant strains, thus being a major public health threat. In this study, we report that Enterobacteriaceae-reactive memory Th cells were highly enriched in a CCR6

Indexed as

CD4-Positive T-LymphocytesCells, CulturedCross ReactionsEnterobacteriaceaeEpitopes, T-LymphocyteHumansImmunologic MemoryInterferon-gammaInterleukin-17Interleukin-22InterleukinsReceptors, Antigen, T-Cell, alpha-betaTh17 CellsTh1 CellsT-Lymphocyte SubsetsEpitopes, T-LymphocyteInterferon-gammaInterleukin-17Interleukin-22InterleukinsReceptors, Antigen, T-Cell, alpha-betacross-reactivityEnterobacteriaceaehuman memory T cellshuman naïve T cellsTh1*/17

Identifiers

PMID33226131
PMCPMC7986685

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.