ArticleVeterinary research2020
Cannabis-derived cannabidiol and nanoselenium improve gut barrier function and affect bacterial enzyme activity in chickens subjected to C. perfringens challenge.
Article in Veterinary research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- β-Thujaplicin modulates the ODC-ROS-linked apoptosis in H460 lung cancer cells.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Phytogenic as a natural resource for gut health management: a sustainable strategy for modern poultry production.Veterinary and animal science · 2026Review
- Solid-state fermentation of hemp waste: enhancing the performance ofFrontiers in bioengineering and biotechnology · 2025Article
- Cannabidiol and nano-selenium mediate intestinal barrier function by affecting mucosal microstructures, and gut-associated immunological and oxidative stress response in the gut of chickens infected withFrontiers in immunology · 2025Article
- Effects of Glutamine or Glucose Deprivation on Inflammation and Tight Junction Disruption in Yak Rumen Epithelial Cells.Animals : an open access journal from MDPI · 2024Article
- Interaction Between Peroxisome Proliferator-Activated Receptors and Cannabidiol in the Gut of Chickens Applied to Different Challenge Conditions.International journal of molecular sciences · 2024Article
- Cannabidiol can affect morphology, morphometry, enzymatic and microbial activity of rabbit digestive system.Journal of animal science · 2024Article
- Effects of Dietary Ferulic Acid on Intestinal Health and Ileal Microbiota of Tianfu Broilers Challenged with Lipopolysaccharide.Molecules (Basel, Switzerland) · 2023Article
- Anti-Inflammatory and Antioxidative Phytogenic Substances against Secret Killers in Poultry: Current Status and Prospects.Veterinary sciences · 2023Review
- CBD resistantFrontiers in medicine · 2023Article
- Cannabidiol and Nano-Selenium Increase Microvascularization and Reduce Degenerative Changes in Superficial Breast Muscle inInternational journal of molecular sciences · 2022Article
- Modulatory Effect of Gut Microbiota on the Gut-Brain, Gut-Bone Axes, and the Impact of Cannabinoids.Metabolites · 2022Review
- The effect of metal-containing nanoparticles on the health, performance and production of livestock animals and poultry.The veterinary quarterly · 2022Review
- Cannabidiol affects breast meat volatile compounds in chickens subjected to different infection models.Scientific reports · 2022Article
- Hemp in Animal Diets-Cannabidiol.Animals : an open access journal from MDPI · 2022Review
- Exopolymer-Functionalized Nanoselenium fromPolymers · 2022Article
- Changes in lipids metabolism indices as a result of different form of selenium supplementation in chickens.Scientific reports · 2022Article
- Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry.Microorganisms · 2022Review
- Role of Gut Microbiota in Cannabinoid-Mediated Suppression of Inflammation.Advances in drug and alcohol research · 2022Article
- Phytogenic Ingredients from Hops and Organic Acids Improve Selected Indices of Welfare, Health Status Markers, and Bacteria Composition in the Caeca of Broiler Chickens.Animals : an open access journal from MDPI · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Revealing the multifocal mechanisms affecting cross-talk between Clostridium perfringens pathogenesis and the host response is an urgent need in the poultry industry. Herein, the activity of Cannabis sativa-derived cannabidiol (CBD) and selenium nanoparticles (Nano-Se) in modulating the host response to Clostridium perfringens challenge was investigated in broiler chickens subjected to a mild infection model. The infected chickens exhibited no clinical manifestations, confirming the potential hazard of pathogen transmission to the food chain in the commercial sector. However, both CBD and Nano-Se affected the responses of chickens to C. perfringens challenge. The beneficial actions of both agents were manifested in the upregulated expression of genes determining gut barrier function. Both CBD and Nano-Se promoted shifts in gut bacterial enzyme activity to increased energy uptake in challenged chickens and upregulated potential collagenase activity. There was no opposite effect of CBD and Nano-Se in mediating the host response to challenge, whereas an additive effect was evidenced on the upregulation of gene determining gut integrity. Collectively, these findings indicate that understanding the action mechanisms of CBD and Nano-Se is of great interest for developing a preventive strategy for C. perfringens infection in broilers.
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Registered trials
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