ArticleCritical care (London, England)2020
Nasal high flow higher than 60 L/min in patients with acute hypoxemic respiratory failure: a physiological study.
Article in Critical care (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06824220 (Effect of High-Flow Tracheal Oxygen on End-Expiratory Lung Impedance in Tracheostomized Patients), which is not on this map. Cited by 27 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of High-Flow Tracheal Oxygen on End-Expiratory Lung Impedance in Tracheostomized Patients
Who cites it
27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- The predictive value of newborn and infant lung ultrasound score for mechanical ventilation needs: a systematic review and meta-analysis.Frontiers in pediatrics · 2025Pooled it
- The effects of flow settings during high-flow nasal cannula support for adult subjects: a systematic review.Critical care (London, England) · 2023Pooled it
- Performance of an indigenously developed high-flow nasal cannula device in healthy human volunteers.BMC anesthesiology · 2026Trial
- Effect of Flow Rates of High-Flow Nasal Cannula on Extubation Outcomes: A Randomized Controlled Trial.Chest · 2025Trial
- Factors influencing nasal airway pressure and comfort in high-flow nasal cannula oxygen therapy: a volunteer study.BMC pulmonary medicine · 2023Trial
- EIT-guided chest physiotherapy for airway clearance during awake prone ventilation in ARDS: a randomized controlled trial.Journal of thoracic disease · 2025Article
- Application of high-flow nasal oxygen during anesthesia induction for frame-based stereoelectroencephalography: a randomized controlled non-inferiority trial.Perioperative medicine (London, England) · 2025Article
- A Novel Approach to High-flow Nasal Oxygen Delivery: Physiological and Clinical Perspectives on Asymmetrical Cannulas.Thoracic research and practice · 2025Article
- Electrical impedance tomography: from technical innovations to bedside clinical solutions.World journal of emergency medicine · 2025Article
- Gas composition and pressure in the hypopharynx during high-flow oxygen therapy through a nasal cannula in healthy volunteers with different breathing patterns.BMC anesthesiology · 2025Article
- High-flow nasal oxygen is the reference treatment in acute hypoxemic respiratory failure: Pro.Journal of intensive medicine · 2025Review
- Digital twins suggest a mechanistic basis for differing responses to increased flow rates during high-flow nasal cannula therapy.Intensive care medicine experimental · 2025Article
- Lessons Learned From Awake ECMO Approach in Covid-19-Related Acute Respiratory Distress Syndrome - a Scoping Review.Therapeutics and clinical risk management · 2025Review
- Combining OJournal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2024Review
- Lung Volume and Ventilation Distribution After Bariatric Surgery: High-Flow Nasal Cannula Versus CPAP.Respiratory care · 2024Article
- Personalized Noninvasive Respiratory Support in the Perioperative Setting: State of the Art and Future Perspectives.Journal of personalized medicine · 2023Review
- High-Flow Nasal Cannula Oxygen Therapy in the Management of Respiratory Failure: A Review.Cureus · 2023Review
- Article
- Comparison of the efficacy and comfort of high-flow nasal cannula with different initial flow settings in patients with acute hypoxemic respiratory failure: a systematic review and network meta-analysis.Journal of intensive care · 2023Article
- Effects of an asymmetrical high flow nasal cannula interface in hypoxemic patients.Critical care (London, England) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNasal high flow delivered at flow rates higher than 60 L/min in patients with acute hypoxemic respiratory failure might be associated with improved physiological effects. However, poor comfort might limit feasibility of its clinical use.
methodsWe performed a prospective randomized cross-over physiological study on 12 ICU patients with acute hypoxemic respiratory failure. Patients underwent three steps at the following gas flow: 0.5 L/kg PBW/min, 1 L/kg PBW/min, and 1.5 L/kg PBW/min in random order for 20 min. Temperature and FiO
resultsIn five patients, the etiology was pulmonary; infective disease characterized seven patients; median PaO
conclusionsNHF delivered at rates higher than 60 L/min in critically ill patients with acute hypoxemic respiratory failure is associated with reduced respiratory rate, increased lung homogeneity, and additional positive pressure effect, but also with worse comfort.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.