Evidence map›Paper›PMID 33225931›Full record

ArticleBMC urology2020

Surgical findings in cryptorchidism in children with Zika-related microcephaly: a case series.

Rômulo A L de Vasconcelos, Ricardo A A Ximenes, Adriano A Calado, Celina M T Martelli, Andreia V Gonçalves, Elizabeth B Brickley, Thalia V B de Araújo, Maria A W Rocha, Demócrito de B Miranda-Filho

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Rômulo A L de VasconcelosUniversidade de Pernambuco, Rua Arnóbio Marques, 310 - Santo Amaro, Recife, PE, 50100-130, Brazil. romulo.alv@hotmail.com.ORCID http://orcid.org/0000-0002-1166-2099
Ricardo A A XimenesUniversidade de Pernambuco, Rua Arnóbio Marques, 310 - Santo Amaro, Recife, PE, 50100-130, Brazil.
Adriano A CaladoUniversidade de Pernambuco, Rua Arnóbio Marques, 310 - Santo Amaro, Recife, PE, 50100-130, Brazil.
Celina M T MartelliInstituto de Pesquisa Aggeu Magalhães - Fiocruz, Recife, Pernambuco, Brazil.
Andreia V GonçalvesUniversidade de Pernambuco, Rua Arnóbio Marques, 310 - Santo Amaro, Recife, PE, 50100-130, Brazil.
Elizabeth B BrickleyLondon School of Hygiene and Tropical Medicine, London, UK.
Thalia V B de AraújoUniversidade Federal de Pernambuco, Recife, Brazil.
Maria A W RochaUniversidade de Pernambuco, Rua Arnóbio Marques, 310 - Santo Amaro, Recife, PE, 50100-130, Brazil.
Demócrito de B Miranda-FilhoUniversidade de Pernambuco, Rua Arnóbio Marques, 310 - Santo Amaro, Recife, PE, 50100-130, Brazil. demofilho@gmail.com.
Universidade de Santo Amaro · BRUniversidade Federal de Pernambuco · BRFundação Oswaldo Cruz · BRLondon School of Hygiene & Tropical Medicine · GBUniversidade de Pernambuco · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 306708/2014-0Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 309722/2017-9Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 440839/2016-5Department for International Development 205377/Z/16/ZFundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco APQ-0192-4.01/17Horizon 2020 734584Medical Research Council MC_PC_15088Ministério da Saúde 837058/2016Newton Fund MC_PC_15088Wellcome TrustWellcome Trust 107779/Z/15/ZWellcome Trust 201870/Z/16/Z
6 · The paper itself

Abstract

backgroundComplications in the urinary tract related to congenital Zika syndrome have recently been reported. One complication, cryptorchidism, has been reported by the Microcephaly Epidemic Research Group/MERG, in Pernambuco/Brazil. The present article describes for the first time the surgical findings in a case series of boys with Zika-related microcephaly and cryptorchidism, who underwent surgical testicular exploration as a contribution to better understand the possible mechanisms involved in gonads formation and descent.

methodsA total of 7 children (11 testicular units), aged 3 to 4 years, were submitted to inguinal or scrotal orchidopexy for the treatment of palpable cryptorchidism between August 2019 and January 2020. Characteristics of the gonads and its annexes related to appendixes, testis-epididymis dissociation, gubernacular insertion, and associated hydroceles and/or hernias were described. Measures in centimetres were taken for volume calculate.

resultsWe found a low prevalence of testicular and epididymal appendix (66.7%), a high prevalence of testis-epididymis dissociation (55.6%), low mean testicular volume for their ages (lower for older boys) and ectopic gubernacular insertion in all cases. There was no evidence of associated hydroceles and/or hernias in any case. No surgical complication was registered or reported, and all explored gonads were properly placed in the scrotal sac.

conclusionsWe herein describe the surgical findings of these children's orchidopexies and discuss the possible mechanisms of viral action in embryogenesis and postnatal growth and development of the testes and annexes. These children need to be followed over time due to the higher risk of testicular atrophy and malignancy. Surgical timing seems to be relevant to avoid loss of testicular volume.

Indexed as

OrchiopexyChild, PreschoolCryptorchidismDiagnostic Techniques, SurgicalHumansMaleMicrocephalyTesticular DiseasesZika Virus InfectionCase seriesCongenital Zika syndromeCryptorchidismMicrocephalyOrchiopexySurgeryZika virus

Identifiers

PMID33225931
PMCPMC7681962
OpenAlexW3108793833

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.