Evidence map›Paper›PMID 33225922›Full record

ArticleBMC medical genetics2020

Genome-wide association study of prevalent and persistent cervical high-risk human papillomavirus (HPV) infection.

Sally N Adebamowo, Adebowale A Adeyemo, Charles N Rotimi, Olayinka Olaniyan, Richard Offiong, Clement A Adebamowo, H3Africa ACCME Research Group

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Sally N AdebamowoDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, 660 West Redwood Street, Howard Hall, Room 119, Baltimore, MD, 21201, USA. sadebamowo@som.umaryland.edu.ORCID 0000-0003-4713-2433
Adebowale A AdeyemoCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Charles N RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA.
Olayinka OlaniyanDepartment of Obstetrics and Gynecology, National Hospital Abuja, Abuja, Nigeria.
Richard OffiongDepartment of Obstetrics and Gynecology, University of Abuja Teaching Hospital, Abuja, Nigeria.
Clement A AdebamowoDepartment of Epidemiology and Public Health, University of Maryland School of Medicine, 660 West Redwood Street, Howard Hall, Room 119, Baltimore, MD, 21201, USA.
H3Africa ACCME Research Group
National Institutes of Health · USUniversity of Maryland, Baltimore · USNational Hospital Abuja · NGUniversity of Abuja Teaching Hospital · NG

Funding

African Collaborative Center for Microbiome and Genomics Research (ACCME)U54HG006947 · NHGRI · INSTITUTE OF HUMAN VIROLOGY · PI ADEBAMOWO, CLEMENT ADEBAYO · 2013 to 2018
$5.7M
Capacity Development for Research into AIDS Associated malignancies (CADRE)D43CA153792 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI ADEBAMOWO, CLEMENT ADEBAYO · 2010 to 2013
$1.8M
American Cancer Society IRG-18-160-16National Institutes of Health (US) 1D43CA153792–01NCI NIH HHS D43 CA153792NHGRI NIH HHS U54 HG006947NIH HHS 1U54HG006947
6 · The paper itself

Abstract

backgroundGenetic factors may influence the susceptibility to high-risk (hr) human papillomavirus (HPV) infection and persistence. We conducted the first genome-wide association study (GWAS) to identify variants associated with cervical hrHPV infection and persistence.

methodsParticipants were 517 Nigerian women evaluated at baseline and 6 months follow-up visits for HPV. HPV was characterized using SPF

resultsThe mean (±SD) age of the study participants was 38 (±8) years, 48% were HIV negative, 24% were hrHPV positive and 10% had persistent hrHPV infections. No single variant reached genome-wide significance (p < 5 X 10

conclusionsThis exploratory GWAS yielded suggestive candidate risk loci for cervical hrHPV infection and persistence. The identified loci have biological annotation and functional data supporting their role in hrHPV infection and persistence. Given our limited sample size, larger discovery and replication studies are warranted to further characterize the reported associations.

Indexed as

Polymorphism, Single NucleotideAdultApoptosis Regulatory ProteinsCase-Control StudiesFemaleGenetic LociGenome-Wide Association StudyHaplotypesHIV InfectionsHumansIntronsKruppel-Like Transcription FactorsMicroRNAsMiddle AgedModels, GeneticNigeriaApoptosis Regulatory ProteinsDAP protein, humanKLF12 protein, humanKruppel-Like Transcription FactorsMicroRNAsMIRN365 microRNA, humanNR5A2 protein, humanReceptors, Cytoplasmic and Nuclear

Identifiers

PMID33225922
PMCPMC7682060
OpenAlexW3108391490

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.