Evidence map›Paper›PMID 33225919›Full record

ArticleBMC infectious diseases2020

Insufficient tuberculosis treatment leads to earlier and higher mortality in individuals co-infected with HIV in southern China: a cohort study.

Zhigang Zheng, Eric J Nehl, Chongxing Zhou, Jianjun Li, Zhouhua Xie, Zijun Zhou, Hao Liang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Zhigang ZhengDepartment of Epidemiology and Statistic, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China.
Eric J NehlDepartment of Behavioral Sciences and Health Education, Rollins School of Public Health, Emory University, Atlanta, 30322, GA, U.S.A.
Chongxing ZhouAIDS Program, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, 18 Jin Zhou Road, Nanning, 530028, China.
Jianjun LiAIDS Program, Guangxi Zhuang Autonomous Region Center for Disease Control and Prevention, 18 Jin Zhou Road, Nanning, 530028, China.
Zhouhua XieHIV/TB Treatment Department, the Fourth Hospital of Nanning City, Nanning, 530023, China.
Zijun ZhouHIV/TB Treatment Department, the Fourth Hospital of Nanning City, Nanning, 530023, China.
Hao LiangGuangxi Key Laboratory of AIDS Prevention and Treatment, School of Public Health, Guangxi Medical University, Nanning, 530021, Guangxi, China. lianghao@gxmu.edu.cn.ORCID http://orcid.org/0000-0001-8627-1263
Guangxi Center for Disease Prevention and Control · CNThe Fourth People's Hospital · CNEmory University · USGuangxi Medical University · CNGuangxi University · CN

Funding

Expanded and Applied Project of Appropriate Technology of Medicine and Health in Guangxi No. S201682The National Nature Science Foundation of China No. 81760618
6 · The paper itself

Abstract

backgroundTuberculosis (TB) and Acquired Immune Deficiency Syndrome (AIDS) are leading causes of death globally. However, little is known about the long-term mortality risk and the timeline of death in those co-infected with human immunodeficiency virus (HIV) and Mycobacterium tuberculosis (MTB). This study sought to understand the long-term mortality risk, factors, and the timeline of death in those with HIV-Mycobacterium tuberculosis (MTB) coinfection, particularly in those with insufficient TB treatment.

methodsTB-cause specific deaths were classified using a modified 'Coding of Cause of Death in HIV' protocol. A longitudinal cross-registration-system checking approach was used to confirm HIV/MTB co-infection between two observational cohorts. Mortality from the end of TB treatment (6 months) to post-treatment year (PTY) 5 (60 months) was investigated by different TB treatment outcomes. General linear models were used to estimate the mean mortality at each time-point and change between time-points. Cox's proportional hazard regressions measured the mortality hazard risk (HR) at each time-point. The Mantel-Haenszel stratification was used to identify mortality risk factors. Mortality density was calculated by person year of follow-up.

resultsAt the end point, mortality among patients with HIV/MTB coinfection was 34.7%. From the end of TB treatment to PTY5, mortality and loss of person years among individuals with TB treatment failure, missing, and adverse events (TBFMA) were significantly higher than those who had TB cure (TBC) and TB complete regimen (TBCR). Compared to individuals with TBC and with TBCR, individuals with TBFMA tended to die earlier and their mortality was significantly higher (HR

conclusionsEarlier and long-term mortality among those with HIV/MTB co-infection is a significant problem when TB treatment fails or is inadequate.

Indexed as

AdultAgedAIDS-Related Opportunistic InfectionsAntitubercular AgentsChinaCoinfectionFemaleFollow-Up StudiesHIVHumansMaleMiddle AgedMycobacterium tuberculosisRisk FactorsSurvival RateTreatment OutcomeAntitubercular Agents

Identifiers

PMID33225919
PMCPMC7682080
OpenAlexW3108783633

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.