Observational studyBMC anesthesiology2020
C-reactive protein concentration as a risk predictor of mortality in intensive care unit: a multicenter, prospective, observational study.
Observational study in BMC anesthesiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Effects of vitamin D supplementation on blood markers in ulcerative colitis patients: a systematic review and meta-analysis.European journal of nutrition · 2022Pooled it
- Prognostic associations of urine output in AKI and dialysis vintage in ESKD at continuous kidney replacement therapy initiation in ICU patients.Journal of intensive care · 2026Article
- Prognostic Value of 72-h Reassessment Using SOFA Score, C-Reactive Protein, and Lactate in a 72-h Landmark Cohort of Intensive Care Patients with Gram-Negative Sepsis.Medicina (Kaunas, Lithuania) · 2026Article
- Comparison of the Predictive Value of CRP/Albumin, CRP/Prealbumin, and the Clinical Frailty Scale for Mortality in Geriatric Intensive Care Patients.Saudi medical journal · 2026Article
- Development and temporal validation of SCRAPS scoring tool to predict poor prognosis in gram negative sepsis patients requiring early intensive care or high dependency unit admission.BMC infectious diseases · 2026Observational
- Comparison between the NUTRIC score and modified NUTRIC score to predict hospital mortality in patients undergoing cardiac surgery: A retrospective study.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2026Article
- Serial C-Reactive Protein Measurements for Prognostication and Antimicrobial Decision-Making in ICU Sepsis Patients: A Retrospective Cohort Study.International journal of general medicine · 2026Article
- Prevalence, Clinical Severity, and Outcomes of Extensively Drug-Resistant and Pan-Drug-Resistant Gram-Negative Infections in a Tertiary Intensive Care Unit: A Retrospective Observational Study.Infection and drug resistance · 2026Article
- Carbapenem-resistantFrontiers in medicine · 2026Article
- Association between mean corpuscular hemoglobin concentration and mortality in ICU patients with acute kidney injury: a retrospective multicenter cohort study.European journal of medical research · 2025Article
- Prospective Evaluation of Clinical and Laboratory Profiles of Febrile and Afebrile Immunosuppressed Patients Presenting to the Emergency Department.Medicina (Kaunas, Lithuania) · 2025Article
- Association of Inflammatory and Metabolic Markers with Mortality in Patients with Postoperative Femur Fractures in the Intensive Care Unit.Medicina (Kaunas, Lithuania) · 2025Article
- Clinical characteristics and prognostic factors of sepsis in patients with malignancy.Scientific reports · 2025Observational
- Optical Bionanosensors for Sepsis Diagnostics.Small (Weinheim an der Bergstrasse, Germany) · 2025Review
- Donor and recipient risk assessment and its influence on clinical outcome in heart transplantation at a reference center in Brazil.JHLT open · 2024Article
- Tei Index and its Relation to Outcome of Critically Ill Children on Continuous Renal Replacement Therapy.Indian journal of pediatrics · 2024Article
- Article
- The role of serum magnesium in the prediction of acute kidney injury after total aortic arch replacement: A prospective observational study.Journal of medical biochemistry · 2024Article
- Association of C-reactive protein with all-cause and cause-specific mortality in people with gout.European journal of medical research · 2024Article
- A Secondary Retrospective Analysis of the Predictive Value of Neutrophil-Reactive Intensity (NEUT-RI) in Septic and Non-Septic Patients in Intensive Care.Diagnostics (Basel, Switzerland) · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundIt is not clear whether there are valuable inflammatory markers for prognosis judgment in the intensive care unit (ICU). We therefore conducted a multicenter, prospective, observational study to evaluate the prognostic role of inflammatory markers.
methodsThe clinical and laboratory data of patients at admission, including C-reactive protein (CRP), were collected in four general ICUs from September 1, 2018, to August 1, 2019. Multivariate logistic regression was used to identify factors independently associated with nonsurvival. The area under the receiver operating characteristic curve (AUC-ROC), net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to evaluate the effect size of different factors in predicting mortality during ICU stay. 3 -knots were used to assess whether alternative cut points for these biomarkers were more appropriate.
resultsA total of 813 patients were recruited, among whom 121 patients (14.88%) died during the ICU stay. The AUC-ROC values of PCT and CRP for discriminating ICU mortality were 0.696 (95% confidence interval [CI], 0.650-0.743) and 0.684 (95% CI, 0.633-0.735), respectively. In the multivariable analysis, only APACHE II score (odds ratio, 1.166; 95% CI, 1.129-1.203; P = 0.000) and CRP concentration > 62.8 mg/L (odds ratio, 2.145; 95% CI, 1.343-3.427; P = 0.001), were significantly associated with an increased risk of ICU mortality. Moreover, the combination of APACHE II score and CRP > 62.8 mg/L significantly improved risk reclassification over the APACHE II score alone, with NRI (0.556) and IDI (0.013). Restricted cubic spline analysis confirmed that CRP concentration > 62.8 mg/L was the optimal cut-off value for differentiating between surviving and nonsurviving patients.
conclusionCRP markedly improved risk reclassification for prognosis prediction.
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