Evidence map›Paper›PMID 33225714›Full record

ArticleCell transplantation

Antishock Characteristics of Erythrocyte-mediated Endoplasmic Reticulum Stress in Macrophages in Severe Hemorrhagic Shock Environment Based on TLR9-cGAS-STING-IFN Signal Axis.

Yi-Qun Kang, Xiao-Hong Yuan, Zhen-Zhou Li, Huan Wang, Xiao-Fang Zhou, Xiao-Xiao Wang, Zi-Wei Zhang, Yu-Feng Feng, Jian-Rong Guo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yi-Qun KangDepartment of Anesthesiology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, P.R. China.
Xiao-Hong YuanDepartment of Anesthesiology, Institute of Cancer Research and Basic Medical Sciences of Chinese Academy of Sciences, Cancer Hospital of University of Chinese Academy of Sciences, Zhejiang Cancer Hospital, Zhejiang, P.R. China.
Zhen-Zhou LiNingxia Medical University, Gongli Hospital of Shanghai Pudong New Area Training Base, Shanghai, P.R. China.
Huan WangDepartment of Anesthesiology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, P.R. China.
Xiao-Fang ZhouDepartment of Anesthesiology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, P.R. China.
Xiao-Xiao WangDepartment of Anesthesiology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, P.R. China.
Zi-Wei ZhangDepartment of Anesthesiology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, P.R. China.
Yu-Feng FengDepartment of Anesthesiology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Jian-Rong GuoDepartment of Anesthesiology, Shanghai Gongli Hospital, The Second Military Medical University, Shanghai, P.R. China.ORCID 0000-0002-3995-2995
Second Military Medical University · CNFirst Affiliated Hospital of Xiamen University · CNHealth First · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the protective effects of erythrocyte-mediated endoplasmic reticulum (ER) stress in macrophages in hemorrhagic shock. An hemorrhagic shock model was established in male BALB/c mice. Animals were randomly divided into three groups (

Indexed as

Endoplasmic Reticulum StressActivating Transcription Factor 6AnimalsApoptosisCalciumCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseCytoplasmErythrocytesInflammationInterferonsMacrophagesMaleMembrane ProteinsMice, Inbred BALB CNucleotidyltransferasesProtein Serine-Threonine KinasesActivating Transcription Factor 6Atf6 protein, mouseCalciumcGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseErn2 protein, mouseInterferonsMembrane ProteinsNucleotidyltransferasesProtein Serine-Threonine KinasesSting1 protein, mouseSTING ProteinToll-Like Receptor 9TLR9TLR9-cGAS-STING-IFN

Identifiers

PMID33225714
PMCPMC7784501
OpenAlexW3109253811

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.