Evidence map›Paper›PMID 33225584›Full record

ArticleEarly intervention in psychiatry2021

Eye movement desensitization and reprocessing therapy for psychosis (EMDRp): Protocol of a feasibility randomized controlled trial with early intervention service users.

Filippo Varese, William Sellwood, Saadia Aseem, Yvonne Awenat, Leanne Bird, Gita Bhutani, Lesley-Anne Carter, Linda Davies, Claire Davis, Georgia Horne and 7 more

Open access · hybridAbstract readClinical Trial Protocol
In one paragraph

Article in Early intervention in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. An etiological approach to psychosis: potential benefits for treatment, research and prevention.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article
  2. The Relationship Between Trauma Exposure and Nonclinical Psychosis: A Systematic Review and Meta-Analysis.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 6 institutions in 2 countries.

Filippo VareseDivision of Psychology and Mental Health, School of Health Sciences, University of Manchester, Academic Health Science Centre, Manchester, UK.ORCID 0000-0001-7244-598X
William SellwoodDivision of Health Research, Lancaster University, Lancaster, UK.
Saadia AseemDivision of Psychology and Mental Health, School of Health Sciences, University of Manchester, Academic Health Science Centre, Manchester, UK.
Yvonne AwenatDivision of Psychology and Mental Health, School of Health Sciences, University of Manchester, Academic Health Science Centre, Manchester, UK.
Leanne BirdLancashire and South Cumbria NHS Foundation Trust, Preston, UK.
Gita BhutaniLancashire and South Cumbria NHS Foundation Trust, Preston, UK.
Lesley-Anne CarterDivision of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Linda DaviesDivision of Population Health, Health Services Research and Primary Care, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.
Claire DavisLancashire and South Cumbria NHS Foundation Trust, Preston, UK.
Georgia HorneLancashire and South Cumbria NHS Foundation Trust, Preston, UK.
David KeaneLancashire and South Cumbria NHS Foundation Trust, Preston, UK.
Robin LogieLancashire and South Cumbria NHS Foundation Trust, Preston, UK.
Debra MalkinLancashire and South Cumbria NHS Foundation Trust, Preston, UK.
Fiona PotterLancashire and South Cumbria NHS Foundation Trust, Preston, UK.
David van den BergParnassia Psychiatric Institute, Hague, The Netherlands.
Shameem ZiaLancashire and South Cumbria NHS Foundation Trust, Preston, UK.
Richard BentallClinical Psychology Unit, Department of Psychology, University of Sheffield, Sheffield, UK.
Lancashire Care NHS Foundation Trust · GBManchester Academic Health Science Centre · GBGreater Manchester Mental Health NHS Foundation Trust · GBLancaster University · GBParnassia Groep · NLUniversity of Sheffield · GB

Funding

Department of Health PB-PG-0317-20037
6 · The paper itself

Abstract

aimTraumatic events are involved in the development and maintenance of psychotic symptoms. There are few trials exploring trauma-focused treatments as interventions for psychotic symptoms, especially in individuals with early psychosis. This trial will evaluate the feasibility and acceptability of conducting a definitive trial of Eye Movement Desensitization and Reprocessing for psychosis (EMDRp) in people with early psychosis.

methodsSixty participants with first episode psychosis and a history of a traumatic/adverse life event(s)will be recruited from early intervention services in the North West of England and randomized to receive16 sessions of EMDRp + Treatment as Usual (TAU) or TAU alone. Participants will be assessed at baseline, 6 and 12 months post-randomization using several measures of psychotic symptoms, trauma symptoms, anxiety, depression, functioning, service-user defined recovery, health economics indicators and quality of life. Two nested qualitative studies to assess participant feedback of therapy and views of professional stakeholders on the implementation of EMDRp into services will also be conducted. The feasibility of a future definitive efficacy and cost-effectiveness evaluation of EMDRp will be tested against several outcomes, including ability to recruit and randomize participants, trial retention at 6- and 12-month follow-up assessments, treatment engagement and treatment fidelity.

conclusionsIf it is feasible to deliver a multi-site trial of this intervention, it will be possible to evaluate whether EMDRp represents a beneficial treatment to augment existing evidence-based care of individuals with early psychosis supported by early intervention services.

Indexed as

Psychotic DisordersQuality of LifeEye MovementsFeasibility StudiesHumansRandomized Controlled Trials as TopicTreatment OutcomeEMDRfeasibilitypsychosisRCTtrauma

Identifiers

PMID33225584
PMCPMC8451747
OpenAlexW3107845908

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.