Evidence map›Paper›PMID 33225578›Full record

ArticleEarly intervention in psychiatry2021

Behavioural inhibition system sensitivity is no longer associated with psychotic-like experiences after controlling for depression and anxiety symptoms.

Evan M Calvo, Arielle Ered, Seth D Maxwell, Lauren M Ellman

Open access · greenAbstract read
In one paragraph

Article in Early intervention in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Evan M CalvoDepartment of Psychology, College of Liberal Arts, Temple University, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-1298-4188
Arielle EredDepartment of Psychology, College of Liberal Arts, Temple University, Philadelphia, Pennsylvania, USA.
Seth D MaxwellDepartment of Psychology, College of Liberal Arts, Temple University, Philadelphia, Pennsylvania, USA.
Lauren M EllmanDepartment of Psychology, College of Liberal Arts, Temple University, Philadelphia, Pennsylvania, USA.
Temple University · US

Funding

Maternal Inflammation During Pregnancy: Clinical and Neurocognitive Outcomes in Adult OffspringR01MH118545 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ELLMAN, LAUREN M · 2019 to 2023
$3.3M
Fetal exposure to maternal stress and inflammation: Effects on neurodevelopmentR01MH096478 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ELLMAN, LAUREN M · 2012 to 2016
$2.1M
1/3-Community Psychosis Risk Screening: An Instrument Development Study SupplementR01MH112613 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ELLMAN, LAUREN M · 2017 to 2022
$1.8M
The Impact of Stress and Trauma on White Matter Integrity and Psychotic-like ExperiencesF31MH119720 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI ERED, ARIELLE · 2019 to 2021
$52k
NIMH NIH HHS F31 MH119720NIMH NIH HHS R01 MH096478NIMH NIH HHS R01 MH112613NIMH NIH HHS R01 MH118545
6 · The paper itself

Abstract

aimElevated behavioural inhibition system sensitivity has been reported among schizophrenia patients. Yet, no study has investigated the relationship between behavioural inhibition system sensitivity and the occurrence of psychotic-like experiences (subthreshold psychotic symptoms considered to be less severe or impairing), despite evidence that behavioural inhibition system sensitivity is related to other forms of psychopathology known to co-occur with psychotic-like experiences, such as depression and anxiety. Thus, the aim of this study was to assess the relationship between behavioural inhibition system levels and psychotic-like experiences while controlling for depression and anxiety symptoms. We hypothesized that behavioural inhibition system sensitivity would be positively associated with the number of reported psychotic-like experiences, and that this association would be nonsignificant after accounting for depression and anxiety symptoms.

methodsPsychotic-like experiences, behavioural inhibition system sensitivity, depression symptoms, and anxiety symptoms were measured in 1162 young adults. Bivariate correlations were calculated and linear regressions performed to measure the relationship between variables of interest.

resultsPsychotic-like experiences, behavioural inhibition system sensitivity, and symptoms of depression, and anxiety were all significantly and positively correlated with one another. Behavioural inhibition system sensitivity was no longer related to the number of psychotic-like experiences reported after controlling for anxiety symptoms, with and without controlling for depression symptoms. DISCUSSION: These findings suggest that the hypersensitivity to threat observed among individuals reporting higher levels of psychotic-like experiences is likely related to co-occurring depression and anxiety symptoms. Thus, behavioural inhibition system sensitivity may be more reflective of a transdiagnostic phenotype of general psychopathology than specifically related to psychosis.

Indexed as

DepressionPsychotic DisordersAnxietyAnxiety DisordersHumansPsychopathologyattenuated psychosisbehavioural inhibition systemBIS/BASpsychotic-like experiencestransdiagnostic phenotype

Identifiers

PMID33225578
PMCPMC8607495
OpenAlexW3106837446

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.