ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2021
The Relationship of Accelerometer-Assessed Standing Time With and Without Ambulation and Mortality: The WHI OPACH Study.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Global Positioning System Indicators of Community Mobility and Future Health Outcomes Among Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Trial
- Development and evaluation of wrist- and thigh-worn accelerometer algorithms using self-training machine learning models for classification of activity type and posture: towards device placement-agnostic methods in the ProPASS consortium.The international journal of behavioral nutrition and physical activity · 2026Article
- Cleaning and pre-processing of actigraphy data for physical activity and sleep research: a scoping review.Physiological measurement · 2026Article
- Associations of Accelerometer-Measured Physical Activity and Sedentary Behavior With Incident Clinical Osteoporotic Fractures Among Older Women: The Objective Physical Activity and Cardiovascular Health Study.Journal of aging and physical activity · 2026Article
- Distribution of device-measured 24-h movement behaviors in older adults: cross-sectional findings from the HUNT4 study.Scientific reports · 2026Article
- Associations of neighbourhood walkability with patterns of device-measured stepping, standing and sitting.The international journal of behavioral nutrition and physical activity · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Daily physical activity in older adults across levels of care: the HUNT Trondheim 70 + study.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2024Article
- Sedentary Behaviors, Light-Intensity Physical Activity, and Healthy Aging.JAMA network open · 2024Article
- Prospective Associations of Accelerometer-Measured Machine-Learned Sedentary Behavior With Death Among Older Women: The OPACH Study.Journal of the American Heart Association · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- The 24-h activity cycle and cardiovascular outcomes: establishing biological plausibility using arterial stiffness as an intermediate outcome.American journal of physiology. Heart and circulatory physiology · 2023Review
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Lifestyle Changes and Psychological Well-Being in Older Adults During COVID-19 Pandemic.Clinics in geriatric medicine · 2022Review
- Association of Accelerometer-Measured Sedentary Accumulation Patterns With Incident Cardiovascular Disease, Cancer, and All-Cause Mortality.Journal of the American Heart Association · 2022Article
- Accelerometer-Derived Daily Life Movement Classified by Machine Learning and Incidence of Cardiovascular Disease in Older Women: The OPACH Study.Journal of the American Heart Association · 2022Article
- Physical activity intensity profiles associated with cardiometabolic risk in middle-aged to older men and women.Preventive medicine · 2022Article
- Associations of Daily Steps and Step Intensity With Incident Diabetes in a Prospective Cohort Study of Older Women: The OPACH Study.Diabetes care · 2022Article
- Contrasting compositions of sitting, standing, stepping, and sleeping time: associations with glycaemic outcome by diabetes risk.The international journal of behavioral nutrition and physical activity · 2021Article
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8 authors.
Funding
Abstract
backgroundSelf-reported time spent standing has been associated with lower risk of mortality. No previous studies have examined this association using device-measured standing.
methodThis was a prospective cohort study of 5878 older (median age = 80 years), racial/ethnically diverse, community-dwelling women in the WHI Objective Physical Activity and Cardiovascular Health Study (OPACH). Women wore accelerometers for 1 week and were followed for mortality. The study applied previously validated machine learning algorithms to ActiGraph GT3X+ accelerometer data to separately measure time spent standing with and without ambulation. Cox proportional hazards models were used to estimate mortality risk adjusting for potential confounders. Effect modification by age, body mass index, moderate-to-vigorous physical activity, sedentary time, physical functioning, and race/ethnicity was evaluated.
resultsThere were 691 deaths during 26 649 person-years of follow-up through March 31, 2018 (mean follow-up = 4.8 years). In fully adjusted models, all-cause mortality risk was lower among those with more standing without ambulation (quartile [Q] 4 vs Q1 HR = 0.63; 95% CI = 0.49-0.81, p-trend = .003) and more standing with ambulation (Q4 vs Q1 HR = 0.50; 95% CI = 0.35-0.71, p-trend < .001). Associations of standing with ambulation and mortality were stronger among women with above-median sedentary time (HR = 0.51; 95% CI = 0.38-0.68) compared to women with below-median sedentary time (HR = 0.80; 95% CI = 0.59-1.07; p-interaction = .02).
conclusionsIn this prospective study among older women, higher levels of accelerometer-measured standing were associated with lower risks of all-cause mortality. Standing is an achievable approach to interrupting prolonged sedentary time, and if not contraindicated, is a safe and feasible behavior that appears to benefit health in older ages.
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