ArticleBioinformatics (Oxford, England)2021
MiRKAT: kernel machine regression-based global association tests for the microbiome.
Article in Bioinformatics (Oxford, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05009758 (Moving Towards PREcision Medicine In United Airways Disease), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Moving Towards PREcision Medicine In United Airways Disease: Unraveling inflaMmatory Patterns in Asthmatic Patients With or Without Nasal Polyps (PREMIUM) - a Descriptive Pilot Study
Who cites it
22 citing papers in PubMed.
- MiSurv: an Integrative Web Cloud Platform for User-Friendly Microbiome Data Analysis with Survival Responses.Microbiology spectrum · 2023Trial
- Early-life gut microbiome composition and rotavirus vaccine-induced IgA responses in U.S. infants: a longitudinal cohort study.EBioMedicine · 2026Article
- Influence of Gut Microbiota on Immune Responses and Protection in Volunteers Receiving the Live Attenuated Oral ETEC Vaccine ACE257 followed by Virulent ETEC H10407 Challenge.Research square · 2026Article
- Anxiety associated with dietary intake and gut microbiome features in a cross-sectional cohort of sub-clinically anxious young women.medRxiv : the preprint server for health sciences · 2026Article
- Dysbiotic shift in the oral microbiota of patients with Alzheimer's disease compared to their healthy life partners-a combinatorial approach and a paired study design.Alzheimer's research & therapy · 2026Article
- The relationship between the early-life gastrointestinal microbiome and childhood nocturnal cough.The Journal of allergy and clinical immunology · 2025Article
- A unified combination framework for dependent tests with applications to microbiome association studies.Biometrics · 2025Article
- Association of physical activity with gut microbiome among low-income black American adults in the Southern Community Cohort Study.Gut microbes reports · 2025Article
- A unified web cloud computing platform MiMedSurv for microbiome causal mediation analysis with survival responses.Scientific reports · 2024Article
- Dynamics and drivers of fungal communities in a multipartite ant-plant association.BMC biology · 2024Article
- Analysis of Microbiome Data.Annual review of statistics and its application · 2024Article
- MicrobiomeAnalyst 2.0: comprehensive statistical, functional and integrative analysis of microbiome data.Nucleic acids research · 2023Article
- Supervised learning and model analysis with compositional data.PLoS computational biology · 2023Article
- Association between lipid-A-producing oral bacteria of different potency and fractional exhaled nitric oxide in a Norwegian population-based adult cohort.Journal of translational medicine · 2023Article
- The mediating roles of the oral microbiome in saliva and subgingival sites between e-cigarette smoking and gingival inflammation.BMC microbiology · 2023Article
- Comprehensive microbiome causal mediation analysis using MiMed on user-friendly web interfaces.Biology methods & protocols · 2023Article
- Bioinformatic and Statistical Analysis of Microbiome Data.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Integrative web cloud computing and analytics using MiPair for design-based comparative analysis with paired microbiome data.Scientific reports · 2022Article
- IDEAS: individual level differential expression analysis for single-cell RNA-seq data.Genome biology · 2022Article
- Testing microbiome association using integrated quantile regression models.Bioinformatics (Oxford, England) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
summaryDistance-based tests of microbiome beta diversity are an integral part of many microbiome analyses. MiRKAT enables distance-based association testing with a wide variety of outcome types, including continuous, binary, censored time-to-event, multivariate, correlated and high-dimensional outcomes. Omnibus tests allow simultaneous consideration of multiple distance and dissimilarity measures, providing higher power across a range of simulation scenarios. Two measures of effect size, a modified R-squared coefficient and a kernel RV coefficient, are incorporated to allow comparison of effect sizes across multiple kernels. AVAILABILITY AND IMPLEMENTATION: MiRKAT is available on CRAN as an R package. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.