Evidence map›Paper›PMID 33225311›Full record

ArticleBlood cancer discovery2020

Genomic characterization of HIV-associated plasmablastic lymphoma identifies pervasive mutations in the JAK-STAT pathway.

Zhaoqi Liu, Ioan Filip, Karen Gomez, Dewaldt Engelbrecht, Shabnum Meer, Pooja N Lalloo, Pareen Patel, Yvonne Perner, Junfei Zhao, Jiguang Wang and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood cancer discovery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.2field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 33 citations in OpenAlex.

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  14. Review
  15. Article
  16. Plasmablastic lymphoma: An update.International journal of laboratory hematology · 2022
    Review
  17. Article
  18. Towards precision medicine in lymphoid malignancies.Journal of internal medicine · 2022
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 3 countries.

Zhaoqi LiuProgram for Mathematical Genomics, Columbia University, New York, New York.
Ioan FilipProgram for Mathematical Genomics, Columbia University, New York, New York.
Karen GomezProgram for Mathematical Genomics, Columbia University, New York, New York.
Dewaldt EngelbrechtDepartment of Haematology and Molecular Medicine, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Shabnum MeerDepartment of Oral Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Pooja N LallooDepartment of Haematology and Molecular Medicine, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Pareen PatelDepartment of Haematology and Molecular Medicine, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Yvonne PernerDepartment of Anatomical Pathology, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
Junfei ZhaoProgram for Mathematical Genomics, Columbia University, New York, New York.
Jiguang WangDivision of Life Science, Department of Chemical and Biological Engineering, Center for Systems Biology and Human Health and State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Hong Kong SAR, China.ORCID 0000-0002-6923-4097
Laura Pasqualucci *Institute for Cancer Genetics. lp171@cumc.columbia.edu rr2579@cumc.columbia.edu pascale.willem@nhls.ac.za.
Raul Rabadan *Program for Mathematical Genomics, Columbia University, New York, New York. lp171@cumc.columbia.edu rr2579@cumc.columbia.edu pascale.willem@nhls.ac.za.
Pascale Willem *Department of Haematology and Molecular Medicine, National Health Laboratory Service, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. lp171@cumc.columbia.edu rr2579@cumc.columbia.edu pascale.willem@nhls.ac.za.
Columbia University · USNational Health Laboratory Service · ZAColumbia University Irving Medical Center · USUniversity of Hong Kong · HKUniversity of the Witwatersrand · ZA

Funding

Topology of Cancer Evolution and HeterogeneityU54CA193313 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI IAVARONE, ANTONIO, RABADAN, RAUL · 2015 to 2020
$10.4M
Columbia-South Africa Training Program for Research on HIV-associated MalignanciD43CA153715 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI NEUGUT, ALFRED I. · 2010 to 2013
$1.8M
Uncovering Evolutionary History using the Topology of Genomic Data with Applications to HIVR01GM117591 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI RABADAN, RAUL · 2015 to 2018
$1.3M
The coding genome of HIV-associated plasmablastic lymphomas in South AfricaR21CA192854 · NCI · WITS HEALTH CONSORTIUM (PTY), LTD · PI PASQUALUCCI, LAURA, RABADAN, RAUL · 2015 to 2016
$385k
NCI NIH HHS D43 CA153715NCI NIH HHS R21 CA192854NCI NIH HHS U54 CA193313NIGMS NIH HHS R01 GM117591
6 · The paper itself

Abstract

Plasmablastic lymphoma (PBL) is an aggressive B-cell non-Hodgkin lymphoma associated with immunodeficiency in the context of Human Immunodeficiency Virus (HIV) infection or iatrogenic immunosuppression. While a rare disease in general, the incidence is dramatically increased in regions of the world with high HIV prevalence. The molecular pathogenesis of this disease is poorly characterized. Here, we defined the genomic features of PBL in a cohort of 110 patients from South Africa (15 by whole exome sequencing and 95 by deep targeted sequencing). We identified recurrent mutations in genes of the JAK-STAT signaling pathway, including

Indexed as

HIV InfectionsLymphoma, Large-Cell, ImmunoblasticPlasmablastic LymphomaGenomicsHumansJanus KinasesMutationSignal TransductionSTAT Transcription FactorsJanus KinasesSTAT Transcription FactorsCD44Epstein Barr virusgeneticsJAK-STATplasmablastic lymphoma

Identifiers

PMID33225311
PMCPMC7679070
OpenAlexW3034839225

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.