ReviewNeuroscience insights2020
The Pathogenesis of Fever-Induced Febrile Seizures and Its Current State.
Review in Neuroscience insights, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- The Genotypic and Phenotypic Spectrum of GOSR2 Mutations: Clinical and Pathophysiological Insights.Journal of inherited metabolic disease · 2025Pooled it
- The non-clinical burden of febrile seizures: a systematic review.Frontiers in pediatrics · 2024Pooled it
- An interpretable machine learning model for predicting febrile seizures following enterovirus infection in children.Annals of medicine · 2026Article
- Integrated Multiomics Reveals Gut-Brain Axis Dysregulation and Phenotype-Specific Metabolic Signatures in Children with Febrile Seizures.Biomedicines · 2026Article
- TREM2-mediated microglial phagocytosis of inhibitory synapses contributes to prolonged FS-induced epileptogenesis.Cell death discovery · 2026Article
- Febrile Seizures in Children in a Low-Resource Setting: A Hospital-Based Cross-Sectional Study from Eastern Libya.Avicenna journal of medicine · 2026Article
- Neuroimmune-driven abrupt neuropsychiatric symptoms in children: preventing pathological fear consolidation.Frontiers in psychiatry · 2026Article
- Article
- BBB proteomic analysis reveals that complex febrile seizures in infancy enhance susceptibility to epilepsy in adulthood through dysregulation of ECM-receptor interaction signaling pathway.Fluids and barriers of the CNS · 2025Article
- Diagnostic Value of IL-4, IL-10, and Neutrophil/Lymphocyte Ratio in Febrile Seizures During Viral Epidemic Period.Molecular neurobiology · 2025Article
- Curcumin attenuates neuroinflammation and improves cognitive function in a rat model of febrile convulsions.Scientific reports · 2025Article
- Febrile temperature-regulated TRPV1 in CD4Journal of neuroinflammation · 2025Article
- Association of Hypocapnia With Febrile Seizures: A Cross-Sectional Observational Study.Cureus · 2025Article
- Effect of environmental exposome and influenza infection on febrile seizure in children over 22 years: a time series analysis.International journal of biometeorology · 2024Article
- Simple febrile seizure et causa bronchopneumonia with complex congenital heart disease.Global cardiology science & practice · 2024Review
- Neuroinflammation increases oxygen extraction in a mouse model of Alzheimer's disease.Alzheimer's research & therapy · 2024Article
- An overview of risk factors in children with febrile seizures.La Tunisie medicale · 2024Review
- Seizures in Children with Influenza during the 2022-2023 Winter Season, a Case Series.Clinics and practice · 2024Article
- Modeling Alzheimer's disease using human cell derived brain organoids and 3D models.Frontiers in neuroscience · 2024Review
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Febrile seizures, commonly in children between the ages of 3 months to 5 years, are a neurological abnormality characterized by neuronal hyper-excitability, that occur as a result of an increased core body temperature during a fever, which was caused by an underlying systemic infection. Such infections cause the immune system to elicit an inflammatory response resulting in the release of cytokines from macrophages. The cytokines such as interleukin (IL)- 1β, IL-6, and tumour necrosis factor-α (TNF-α) combat the infection in the localized area ultimately spilling over into circulation resulting in elevated cytokine levels. The cytokines, along with pathogen-associated molecular patterns (PAMPs) expressed on pathogens for example, lipopolysaccharide (LPS), interact with the blood brain barrier (BBB) causing a 'leaky' BBB which facilitates cytokines and LPS entry into the central nervous system. The cytokines activate the microglia which release their own cytokines, specifically IL1β. IL-β interacts with the brain endothelium resulting in the activation of cyclooxygenase 2 which catalyzes the production of prostaglandin 2 (PGE2). PGE2 enters the hypothalamic region and induces a fever. Abnormally increased IL-1β levels also progressively increases excitatory (glutamatergic) neurotransmission, and decreases inhibitory (GABAergic) neurotransmission, thus mediating the pathogenesis of convulsions. Current treatments for febrile seizures present with side effects that are detrimental to health, which fosters the need for an alternative, more affordable treatment with fewer adverse side effects, and 1 that is easily accessible, especially in low income areas that are also affected by other underlying socio-economic factors, in which febrile seizures are of growing concern.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.