ArticleiScience2020
Coordination between Cell Motility and Cell Cycle Progression in Keratinocyte Sheets via Cell-Cell Adhesion and Rac1.
Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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Who cites it
9 citing papers in PubMed, 17 citations in OpenAlex.
- Response of epithelial cell lines from the rainbow trout gut and gill to ammonia.In vitro cellular & developmental biology. Animal · 2026Article
- Identification of PKN2 and MOB4 as Coordinators of Collective Cell Migration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Keratinocyte Capability for Smooth Sheet Formation on a Step Pattern Substrate.Bioengineering (Basel, Switzerland) · 2025Article
- ARHGAP25: a novel player in the Pathomechanism of allergic contact hypersensitivity.Frontiers in immunology · 2025Article
- Proteomic signatures of retinal pigment epithelium-derived exosomes in myopic and non-myopic tree shrew eyes.Frontiers in medicine · 2025Article
- Extracellular Matrix Deposition Defines the Duration of Cell Sheet Assembly from Human Adipose-Derived MSC.International journal of molecular sciences · 2023Article
- Application of Electrochemical Oxidation for Water and Wastewater Treatment: An Overview.Molecules (Basel, Switzerland) · 2023Review
- Article
- Anti-Malignant Effect of Tensile Loading to Adherens Junctions in Cutaneous Squamous Cell Carcinoma Cells.Frontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regulations of cell motility and proliferation are essential for epithelial development and homeostasis. However, it is not fully understood how these cellular activities are coordinated in epithelial collectives. In this study, we find that keratinocyte sheets exhibit time-dependent coordination of collective cell movement and cell cycle progression after seeding cells. Cell movement and cell cycle progression are coordinately promoted by Rac1 in the "early phase" (earlier than ∼30 h after seeding cells), which is not abrogated by increasing the initial cell density to a saturated level. The Rac1 activity is gradually attenuated in the "late phase" (later than ∼30 h after seeding cells), leading to arrests in cell motility and cell cycle. Intact adherens junctions are required for normal coordination between cell movement and cell cycle progression in both early and late phases. Our results unveil a novel basis for integrating motile and proliferative behaviors of epithelial collectives.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.