ArticleNeurological research and practice2020
German guidelines on the diagnosis and treatment of neurosyphilis.
Article in Neurological research and practice, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- The spectrum of movement disorders in neurosyphilis: A systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Clinical presentation of neurosyphilis - a single-center retrospective data analysis.Neurological research and practice · 2026Article
- Diagnostic Challenges of Neurosyphilis: A Case of Lues Maligna with Neuropsychiatric Symptoms.Acta dermato-venereologica · 2026Article
- Jarisch-Herxheimer reaction as a complication of penicillin G and ceftriaxone treatment in neurosyphilis.BMC infectious diseases · 2026Article
- From seropositivity to neurosyphilis: clinical spectrum and diagnostic classification in hospitalized neurology patients: a 16-year retrospective study.Frontiers in neurology · 2026Observational
- Neurosyphilis and Parkinsonism: Overlapping Pathophysiology and Emerging Therapeutic Insights.Current neurovascular research · 2026Review
- Clinical, Radiological, and Pathological Features of Cerebral and Spinal Syphilitic Gumma: A Cross-Sectional Study.International journal of general medicine · 2025Article
- The performance of a novel diagnostic criteria for neurosyphilis in HIV-negative patients.Scientific reports · 2024Article
- Canadian Public Health Laboratory Network (CPHLN) Diagnostic Recommendations for Neurosyphilis in Canada.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2024Article
- Answer to June 2024 Photo Quiz.Journal of clinical microbiology · 2024Article
- Enhancing clinical awareness: retrospective analysis of neurosyphilis cases and diagnostic predictors for early recognition and treatment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Article
- Case report-Depression with psychotic features as an atypical presentation of neurosyphilis.Clinical case reports · 2024Article
- CXCL13 in Cerebrospinal Fluid: Clinical Value in a Large Cross-Sectional Study.International journal of molecular sciences · 2023Article
- Neurosyphilis with oral‑facial‑lingual dyskinesia: A case report.Experimental and therapeutic medicine · 2023Article
- Serological testing for syphilis in the differential diagnosis of cognitive decline and polyneuropathy in geriatric patients.BMC geriatrics · 2023Article
- Comparison of Treponema-specific immunoglobulin G (IgG) index with Treponema pallidum particle agglutination (TPPA) index for detection of intrathecal Treponema-specific antibody synthesis for serological diagnosis of neurosyphilis.GMS infectious diseases · 2023Article
- Neurosyphilis: insights into its pathogenesis, susceptibility, diagnosis, treatment, and prevention.Frontiers in neurology · 2023Review
- Editorial: Neurosyphilis: epidemiology, clinical manifestations, diagnosis, immunology and treatment.Frontiers in medicine · 2023Article
- Cerebral syphilitic gumma mimicking a brain tumor that enlarged temporarily after commencing antibiotic treatment.eNeurologicalSci · 2022Article
- Advances in laboratory diagnostic methods for cerebrospinal fluid testing for neurosyphilis.Frontiers in public health · 2022Review
Corrections and comments
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Authors and funding
10 authors at 10 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIn view of the importance of neurosyphilis and the difficulties encountered in diagnosing it, the S1 guideline "Neurosyphilis" has been published by the German Society for Neurology (DGN) in accordance with the stipulations of the Association of the Scientific Medical Societies in Germany (AWMF). The present article is an abridged translation of that German guideline. MAIN RECOMMENDATIONS: (a) Neurosyphilis can manifest as early neurosyphilis (meningitis, meningovascular neurosyphilis or syphilitic gummas) or late neurosyphilis (tabes dorsalis, general paresis). (b) The following diagnostic criteria help to establish the presence of probable neurosyphilis (always point iv, accompanied by any two of points i to iii): (i) subacute or chronic neuro-psychiatric symptoms; (ii) increased cerebrospinal fluid (CSF) cell count or signs of blood-CSF barrier disruption; (iii) positive effect of anti-neurosyphilis antibiotic therapy on clinical course and CSF findings; (iv) positive TPHA/TPPA or FTA test in serum. (c) The diagnosis of neurosyphilis is confirmed by the subsequent detection of intrathecal production of antibodies against
conclusionThe German guideline on the diagnosis and treatment of neurosyphilis is a practical tool to support clinicians in diagnosing and treating patients with neurosyphilis. This article is an abridged translation of this guideline (Klein MW, J.; Angstwurm, K.; Esser, S.; Hahn, K.; Matschke, M.; Scheithauer, S.; Schoefer, H.; Sturzenegger, M.; Wildemann, B. Neurosyphilis, S1-Leitlinie. Deutsche Gesellschaft für Neurologie, Leitlinien für Diagnostik und Thearpie in der Neurologie 2020).
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