Evidence map›Paper›PMID 33225220›Full record

ArticleEmergent materials2019

Dhavan Sharma, Morgan Ferguson, Timothy J Kamp, Feng Zhao

Open access · greenAbstract read
In one paragraph

Article in Emergent materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 55 citations in OpenAlex.

  1. Human cardiovascular organoids: Biomedical applications and ethical challenges.American heart journal plus : cardiology research and practice · 2026
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  10. Application of human cardiac organoids in cardiovascular disease research.Frontiers in cell and developmental biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Dhavan SharmaDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.
Morgan FergusonDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.
Timothy J KampStem Cell and Regenerative Medicine Center, University of Wisconsin, Madison, WI 53705, USA.
Feng ZhaoDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA.
Michigan Technological University · USUniversity of Wisconsin–Madison · US

Funding

Integrated Cellular and Tissue Engineering for Ischemic Heart DiseaseU01HL134764 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BURSAC, NENAD, KAMP, TIMOTHY J. · 2016 to 2022
$7.7M
Therapeutic Lymphatic Vessel RegenerationR15CA202656 · NCI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI ZHAO, FENG · 2016 to 2016
$465k
Development of Off-the-shelf Completely Biological Small-Diameter Blood Vessel with Human Stem CellsR15HL145654 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI GUILLORY, ROGER J. · 2019 to 2019
$459k
Development of Off-the-shelf Completely Biological Small-Diameter Blood Vessel wiR15HL115521 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI ZHAO, FENG · 2013 to 2013
$410k
NCI NIH HHS R15 CA202656NHLBI NIH HHS R15 HL115521NHLBI NIH HHS R15 HL145654NHLBI NIH HHS U01 HL134764
6 · The paper itself

Abstract

Engineered cardiac patches (ECPs) hold great promise to repair ischemia-induced damages to the myocardium. Recent studies have provided robust technological advances in obtaining pure cardiac cell populations as well as various novel scaffold materials to generate engineered cardiac tissues that can significantly improve electrical and contractile functions of damaged myocardium. Given the significance in understanding the cellular and extracellular structural as well as compositional details of native human heart wall, in order to fabricate most suitable scaffold material for cardiac patches, herein, we have reviewed the structure of the human pericardium and heart wall as well as the compositional details of cardiac extracellular matrix (ECM). Moreover, several strategies to obtain cardiac-specific scaffold materials have been reviewed, including natural, synthetic and hybrid hydrogels, electrospun fibers, decellularized native tissues or whole organs, and scaffolds derived from engineered cell sheets. This review provides a comprehensive analysis of different scaffold materials for engineering cardiac tissues.

Indexed as

Cardiac patch engineeringcardiac tissue regenerationscaffold materials

Identifiers

PMID33225220
PMCPMC7678685
OpenAlexW2964899247

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.