Evidence map›Paper›PMID 33225120›Full record

ArticleIEEE transactions on radiation and plasma medical sciences2020

Quantifying bias and precision of kinetic parameter estimation on the PennPET Explorer, a long axial field-of-view scanner.

Varsha Viswanath, Austin R Pantel, Margaret E Daube-Witherspoon, Robert Doot, Mark Muzi, David A Mankoff, Joel S Karp

Abstract read
In one paragraph

Article in IEEE transactions on radiation and plasma medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. First-in-Human Biodistribution and Dosimetry of [Molecular imaging and biology · 2026
    Article
  2. Article
  3. Article
  4. Total-Body PET System Designs with Axial and Transverse Gaps: A Study of Lesion Quantification and Detectability.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  5. Review
  6. Review
  7. Quantitation of dynamic total-body PET imaging: recent developments and future perspectives.European journal of nuclear medicine and molecular imaging · 2023
    Review
  8. Article
  9. Abbreviated scan protocols to captureEuropean journal of nuclear medicine and molecular imaging · 2022
    Article
  10. First results on kinetic modelling and parametric imaging of dynamicEuropean journal of nuclear medicine and molecular imaging · 2022
    Article
  11. Total-Body PET: Will It Change Science and Practice?Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  12. Principles of Tracer Kinetic Analysis in Oncology, Part II: Examples and Future Directions.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  13. Review
  14. Review
  15. Review
  16. PET Parametric Imaging: Past, Present, and Future.IEEE transactions on radiation and plasma medical sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Varsha ViswanathBioengineering Department, University of Pennsylvania, Philadelphia, PA 19104.
Austin R PantelDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Margaret E Daube-WitherspoonDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Robert DootDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Mark MuziDepartment of Radiology, University of Washington, Seattle, WA 98195.
David A MankoffDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.
Joel S KarpDepartment of Radiology, University of Pennsylvania, Philadelphia, PA 19104.

Funding

Time-of-Flight PET for Improved Whole-Body ImagingR01CA113941 · NCI · UNIVERSITY OF PENNSYLVANIA · PI JOEL S KARP, Suleman Surti · 2006 to 2026
$9.8M
Training Program in Biomedical Imaging and Information SciencesT32EB009384 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI GEE, JAMES C, IVES, ZACHARY · 2009 to 2023
$4.0M
Core Laboratory for Advanced PET and MRI image analysisR50CA211270 · NCI · UNIVERSITY OF WASHINGTON · PI Mark Muzi · 2017 to 2026
$2.6M
Area B: Multi-Tracer Volumetric PET (MTV-PET) to Measure Tumor Glutamine and Glucose Metabolic Rates in a Single Imaging SessionR33CA225310 · NCI · UNIVERSITY OF PENNSYLVANIA · PI KARP, JOEL S, MANKOFF, DAVID A. · 2017 to 2017
$1.4M
NCI NIH HHS R01 CA113941NCI NIH HHS R33 CA225310NCI NIH HHS R50 CA211270NIBIB NIH HHS T32 EB009384
6 · The paper itself

Abstract

Long axial field-of-view (AFOV) PET scanners allow for full-body dynamic imaging in a single bed-position at very high sensitivity. However, the benefits for kinetic parameter estimation have yet to be studied. This work uses (1) a dynamic GATE simulation of [

Indexed as

Dynamic imagingFDGFLTGATE simulationsLesion embeddinglong axial field of view PETPennPET Explorer

Identifiers

PMID33225120
PMCPMC7673289

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.