Evidence map›Paper›PMID 33224990›Full record

ArticleJournal of diabetes research2020

The Alteration in Composition and Function of Gut Microbiome in Patients with Type 2 Diabetes.

Xue Zhao, Yiding Zhang, Ruixue Guo, Wei Yu, Fanliang Zhang, Feng Wu, Jin Shang

Abstract read
In one paragraph

Article in Journal of diabetes research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. mSystems · 2024
    Article
  17. Article
  18. Article
  19. Alterations in the Gut Microbiota Composition in Obesity with and without Type 2 Diabetes: A Pilot Study.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xue ZhaoDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, No. 1 of East Jianshe Road, Zhengzhou, Henan, China 450052.ORCID https://orcid.org/0000-0002-9483-1678
Yiding ZhangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, No. 1 of East Jianshe Road, Zhengzhou, Henan, China 450052.ORCID https://orcid.org/0000-0002-3500-1586
Ruixue GuoDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, No. 1 of East Jianshe Road, Zhengzhou, Henan, China 450052.ORCID https://orcid.org/0000-0002-1858-1443
Wei YuDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, No. 1 of East Jianshe Road, Zhengzhou, Henan, China 450052.
Fanliang ZhangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, No. 1 of East Jianshe Road, Zhengzhou, Henan, China 450052.
Feng WuDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, No. 1 of East Jianshe Road, Zhengzhou, Henan, China 450052.
Jin ShangDepartment of Nephrology, The First Affiliated Hospital of Zhengzhou University, No. 1 of East Jianshe Road, Zhengzhou, Henan, China 450052.ORCID https://orcid.org/0000-0003-2801-7683

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDiabetes mellitus (DM) has become one of the most common chronic metabolic diseases worldwide. Due to the increasing prevalence and various complications, diabetes brings about a huge financial burden to DM patients. Nowadays, more and more studies reveal the relationship between diseases and gut microbial community. We aimed to explore the alteration in composition and function of the gut microbiome in T2DM patients.

methodsA total of 137 patients with diabetes and 179 age- and gender-matched healthy controls selected from the healthy people sample center in the First Affiliated Hospital of Zhengzhou University were divided into the DM group and the Con group, respectively. We collected their venous blood for laboratory tests and stool samples for 16S rRNA sequencing. The comparison between the two groups including both composition and function of the gut microbiome is presented.

resultsWe found that the

conclusionWe observed alteration of composition and function of the gut microbiome in the DM group. These changes may provide a new treatment strategy for DM patients and new research targets.

Indexed as

Gastrointestinal MicrobiomeActinobacteriaAkkermansiaBacteroidesBacteroidetesCase-Control StudiesDiabetes Mellitus, Type 2EnterococcusEscherichiaEubacterialesFemaleHumansMaleMiddle AgedPrevotellaProteobacteriaRNA, Ribosomal, 16S

Identifiers

PMID33224990
PMCPMC7673948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.