ArticleFrontiers in cellular and infection microbiology2020
Mucosal-Associated Microbiota Other Than Luminal Microbiota Has a Close Relationship With Diarrhea-Predominant Irritable Bowel Syndrome.
Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Gut microbial dysbiosis associated to diarrheic irritable bowel syndrome can be efficiently simulated in the Mucosal ARtificial COLon (M-ARCOL).Bioengineered · 2025Article
- Celiac Disease: The Importance of Studying the Duodenal Mucosa-Associated Microbiota.Nutrients · 2024Review
- Gut microbiota predicts severity and reveals novel metabolic signatures in acute pancreatitis.Gut · 2024Article
- Decreasing of Trimethylamine N-Oxide by Cecal Microbiota and Choline-Trimethylamine Lyase are Associated with Sishen Pill on Diarrhea with Kidney-Yang Deficiency Syndrome.Journal of inflammation research · 2024Article
- Supplementation with high-GABA-producing Lactobacillus plantarum L5 ameliorates essential tremor triggered by decreased gut bacteria-derived GABA.Translational neurodegeneration · 2023Article
- Relationship among Chinese herb polysaccharide (CHP), gut microbiota, and chronic diarrhea and impact of CHP on chronic diarrhea.Food science & nutrition · 2023Review
- Exploring the Relationship between the Gut Mucosal Virome and Colorectal Cancer: Characteristics and Correlations.Cancers · 2023Article
- Effects of Shenling Baizhu powder on pyrotinib-induced diarrhea: analysis of gut microbiota, metabonomics, and network pharmacology.Chinese medicine · 2022Article
- Distinctions Between Fecal and Intestinal Mucosal Microbiota in Subgroups of Irritable Bowel Syndrome.Digestive diseases and sciences · 2022Article
- Mucosal Microbiota: Closer to the Pathology, Closer to the Truth?Digestive diseases and sciences · 2022Article
- Relationship between mucosa-associated gut microbiota and human diseases.Biochemical Society transactions · 2022Review
- Article
- Microbiome-based interventions to modulate gut ecology and the immune system.Mucosal immunology · 2022Review
- Intestinal microbiota and its interaction to intestinal health in nursery pigs.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- Human blood vessel microbiota in healthy adults based on common femoral arteries of brain-dead multi-organ donors.Frontiers in cellular and infection microbiology · 2022Article
- Sex hormones influence the intestinal microbiota composition in mice.Frontiers in microbiology · 2022Article
- Microbial communities of poultry house dust, excreta and litter are partially representative of microbiota of chicken caecum and ileum.PloS one · 2021Article
- Management and Mechanisms of Diarrhea Induced by Tyrosine Kinase Inhibitors in Human Epidermal Growth Factor Receptor-2-Positive Breast Cancer.Cancer control : journal of the Moffitt Cancer CenterReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies have linked dysbiosis of gut microbiota to irritable bowel syndrome (IBS). However, dysbiosis only referring to structural changes without functional alteration or focusing on luminal microbiota are incomplete. To fully investigate the relationship between gut microbiota and clinical symptoms of Irritable Bowel Syndrome with Diarrhea (IBS-D), fecal samples, and rectal mucosal biopsies were collected from 69 IBS-D patients and 20 healthy controls (HCs) before and during endoscopy without bowel preparation. 16S rRNA genes were amplified and sequenced, and QIIME pipeline was used to process the composition of microbial communities. PICRUSt was used to predict and categorize microbial function. The composition of mucosa-associated microbiota (MAM) was significantly different in IBS-D patients compared to HCs; while no difference in luminal microbiota (LM). MAM, but not LM, was significantly positively correlated with abdominal pain and bloating. A greater number of MAM functional genes changed in IBS-D patients than that of LM compared with HCs. Metabolic alteration in MAM not in LM was related to abdominal pain and bloating. There was a close relationship between the composition and function of MAM and clinical symptoms in IBS-D patients which suggests the important role of MAM in pathogenesis and therapies in IBS-D and it should be highlighted in the future.
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