Evidence map›Paper›PMID 33224880›Full record

ArticleFrontiers in oncology2020

Noninvasive Detection of Extracellular pH in Human Benign and Malignant Liver Tumors Using CEST MRI.

Yanyan Tang, Gang Xiao, Zhiwei Shen, Caiyu Zhuang, Yudan Xie, Xiaolei Zhang, Zhongxian Yang, Jitian Guan, Yuanyu Shen, Yanzi Chen and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in oncology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 49 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Human liver CEST imaging at 7 T: Impact ofMagnetic resonance in medicine · 2025
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 1 country.

Yanyan TangDepartment of Medical Imaging, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Gang XiaoDepartment of Mathematics and Statistics, Hanshan Normal University, Chaozhou, China.
Zhiwei ShenPhilips Healthcare, Beijing, China.
Caiyu ZhuangDepartment of Medical Imaging, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Yudan XieDepartment of General Surgery, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Xiaolei ZhangCollege of Air Traffic Management, Civil Aviation Flight University of China, Guanghan, China.
Zhongxian YangDepartment of Medical Imaging, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Jitian GuanDepartment of Medical Imaging, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Yuanyu ShenDepartment of Medical Imaging, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Yanzi ChenDepartment of Medical Imaging, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Lihua LaiDepartment of Medical Imaging, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Yuanfeng ChenDepartment of Medical Imaging, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Shuo ChenDepartment of Medical Imaging, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Zhuozhi DaiDepartment of Medical Imaging, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Runrun WangDepartment of Medical Imaging, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Renhua WuDepartment of Medical Imaging, The Second Affiliated Hospital, Shantou University Medical College, Shantou, China.
Second Affiliated Hospital of Shantou University Medical College · CNShantou University · CNCivil Aviation Flight University of China · CNHanshan Normal University · CNPhilips (China) · CNThe Seventh Affiliated Hospital of Sun Yat-sen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeIn this study, we aimed to use 3T magnetic resonance imaging (MRI), which is clinically available, to determine the extracellular pH (pHe) of liver tumors and prospectively evaluate the ability of chemical exchange saturation transfer (CEST) MRI to distinguish between benign and malignant liver tumors.

methodsDifferent radiofrequency irradiation schemes were assessed for ioversol-based pH measurements at 3T. CEST effects were quantified

resultsBy conducting dual-power CEST MRI, the pH of solutions was determined to be 6.0-7.2 at 3T

conclusiondual-power CEST MRI can detect extracellular pH in human liver tumors and can provide molecular-level diagnostic tools for differentiating benign and malignant liver tumors at 3T.

Indexed as

chemical exchange saturation transfer magnetic resonance imaging (MRI)extracellular pHhepatic carcinomahepatic hemangiomaioversol

Identifiers

PMID33224880
PMCPMC7667286
OpenAlexW3097264529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.