Evidence map›Paper›PMID 33224752›Full record

ArticleCardiovascular diagnosis and therapy2020

Left ventricular ischemia in pre-capillary pulmonary hypertension: a cardiovascular magnetic resonance study.

Karthigesh Sree Raman, Ranjit Shah, Michael Stokes, Angela Walls, Richard J Woodman, Rajiv Ananthakrishna, Jennifer G Walker, Susanna Proudman, Peter M Steele, Carmine G De Pasquale and 2 more

Erratum issuedOpen access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular diagnosis and therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Biventricular longitudinal strain analysis using cardiovascular magnetic resonance feature-tracking: Prognostic value in Eisenmenger syndrome.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2024
    Article
  3. Article
  4. [Oxygenation-sensitive cardiac magnetic resonance imaging].Radiologie (Heidelberg, Germany) · 2022
    Review
  5. Review
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 2 countries.

Karthigesh Sree RamanCollege of Medicine and Public Health, Flinders University, Flinders, Australia.
Ranjit ShahCollege of Medicine and Public Health, Flinders University, Flinders, Australia.
Michael StokesDepartment of Cardiology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Angela WallsClinical Research and Imaging Centre, South Australian Health & Medical Research Institute, Adelaide, South Australia, Australia.
Richard J WoodmanFlinders Centre of Epidemiology and Biostatistics, College of Medicine and Public Health, Flinders University, Flinders, Australia.
Rajiv AnanthakrishnaCollege of Medicine and Public Health, Flinders University, Flinders, Australia.
Jennifer G WalkerFlinders Medical Centre, Flinders, Australia.
Susanna ProudmanDiscipline of Medicine, University of Adelaide, Adelaide, Australia.
Peter M SteeleDepartment of Cardiology, Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Carmine G De PasqualeCollege of Medicine and Public Health, Flinders University, Flinders, Australia.
David S CelermajerSydney Medical School, University of Sydney and Royal Prince Alfred Hospital, Sydney, Australia.
Joseph B SelvanayagamCollege of Medicine and Public Health, Flinders University, Flinders, Australia.
Flinders Medical Centre · AUFlinders University · AURoyal Adelaide Hospital · AUNorthland District Health Board · NZSouth Australian Health and Medical Research Institute · AUUniversity of Adelaide · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrognosis in pulmonary arterial hypertension (PAH) is largely dependent on right ventricular (RV) function. However, recent studies have suggested the presence of left ventricular (LV) dysfunction in PAH patients. The potential role of LV ischemia, as a contributor to progressive LV dysfunction, has not been systematically studied in PAH. We aim to assess the presence and extent of LV myocardial ischemia in patients with known PH and without obstructive coronary artery disease (CAD), using oxygen-sensitive (OS) cardiovascular magnetic resonance (CMR) and stress/rest CMR T1 mapping.

methodsWe prospectively recruited 28 patients with right heart catheter-proven PH and no significant CAD, 8 patients with known CAD and 11 normal age-matched controls (NC). OS-CMR images were acquired using a T2* sequence and T1 maps were acquired using Shortened Modified Look-Locker Inversion recovery (ShMOLLI) at rest and adenosine-induced stress vasodilatation; ΔOS-CMR signal intensity (SI) index (stress/rest SI) and ΔT1 reactivity (stress-rest/rest T1 mapping) were calculated.

resultsGlobal LV ΔOS SI index was significantly lower in PH patients compared with controls (11.1%±6.7%

conclusionsDecreased OS-CMR SI and T1 reactivity signify the presence of impaired myocardial oxygenation and vasodilatory response in PH patients. Given their unobstructed epicardial coronary arteries, this is likely secondary to coronary microvascular dysfunction (CMD).

Indexed as

cardiac magnetic resonance (CMR)coronary microvascular dysfunction (CMD)oxygen-sensitive cardiac magnetic resonancePulmonary hypertensionstress/rest T1 mapping

Identifiers

PMID33224752
PMCPMC7666959
OpenAlexW3093843696

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.