Evidence map›Paper›PMID 33224505›Full record

ArticleMaterials horizons2019

Ultralong tumor retention of theranostic nanoparticles with short peptide-enabled active tumor homing.

Lihua Li, Yao Lu, Zefeng Lin, Angelina S Mao, Ju Jiao, Ye Zhu, Chunyan Jiang, Zhongmin Yang, Mingying Peng, Chuanbin Mao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials horizons, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. New anti-cancer explorations based on metal ions.Journal of nanobiotechnology · 2022
    Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lihua LiDevice the State Key Laboratory of Luminescent Materials and Devices, and Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, School of Physics, School of Materials Science and Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510641, China.
Yao LuDepartment of Orthopedics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510282, China.
Zefeng LinGuangdong Key Lab of Orthopedic Technology and Implant, Department of Orthopedics, Guangzhou General Hospital of Guangzhou Military Command, 111 Liuhua Road, Guangzhou, Guangdong 510010, China.
Angelina S MaoNorman North High School, 1809 Stubbeman Ave, Norman, OK 73069, USA.
Ju JiaoDepartment of Nuclear Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, 510630.
Ye ZhuDepartment of Chemistry and Biochemistry, Stephenson Life Sciences Research center, Institute for Biomedical Engineering, Science and Technology, University of Oklahoma, Norman, OK 73019, USA.
Chunyan JiangDevice the State Key Laboratory of Luminescent Materials and Devices, and Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, School of Physics, School of Materials Science and Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510641, China.
Zhongmin YangDevice the State Key Laboratory of Luminescent Materials and Devices, and Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, School of Physics, School of Materials Science and Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510641, China.
Mingying PengDevice the State Key Laboratory of Luminescent Materials and Devices, and Guangdong Provincial Key Laboratory of Fiber Laser Materials and Applied Techniques, School of Physics, School of Materials Science and Engineering, South China University of Technology, 381 Wushan Road, Guangzhou 510641, China.
Chuanbin MaoDepartment of Chemistry and Biochemistry, Stephenson Life Sciences Research center, Institute for Biomedical Engineering, Science and Technology, University of Oklahoma, Norman, OK 73019, USA.

Funding

Virus-based nanoparticles for detecting breast cancer biomarkersR01EB021339 · NIBIB · UNIVERSITY OF OKLAHOMA · PI CAO, BINRUI · 2016 to 2019
$1.4M
NIBIB NIH HHS R01 EB021339
6 · The paper itself

Abstract

Computer tomography (CT) and magnetic resonance imaging (MRI) are noninvasive cancer imaging methods in clinics. Hence, a material that enables MRI/CT dual-modal imaging-guided therapy is in high demand. Currently, the available materials lack active tumor targeting, deep tumor penetration, and ultralong tumor retention and may lose their imaging elements. To overcome these drawbacks, herein, nanoparticles (NPs) were deveopled by integrating an MRI contrast-enhancing chelated gadolinium (Gd) complex within a doxorubicin (DOX)-loaded protective silica shell as well as a CT imaging/photothermal biocompatible bismuth (Bi) nano-core, which surface-displayed an MCF-7 breast tumor-homing peptide (AREYGTRFSLIGGYR, termed AR); we found that the resultant NPs AR-Bi@SiO

Identifiers

PMID33224505
PMCPMC7677965

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.