ArticleJournal of tissue engineering
Porous polylactic acid scaffolds for bone regeneration: A study of additively manufactured triply periodic minimal surfaces and their osteogenic potential.
Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Investigation into the Impact of Hollow Cylinder Inner Diameter on the Mechanical Properties of Biomimetic Voronoi Scaffolds.Journal of functional biomaterials · 2026Article
- Design and Fabrication of Biomimetic Gradient Bone Tissue Engineering Scaffolds: Evolution from Single-Gradient to Multi-Gradient.Gels (Basel, Switzerland) · 2026Review
- An Overview of Additive Manufacturing of Triply Periodic Minimal Surface (TPMS) Structures.Polymers · 2025Review
- Recent Developments in Novel TPMS Lattice Materials: Design Optimization, Performance Control, and Applications in Biomimetic Scaffolds.Materials (Basel, Switzerland) · 2025Review
- Process-Driven Optimization of FDM Porous PEEK Scaffolds for Alloplastic Bone Grafts.ACS omega · 2025Article
- A Neural Network-Accelerated Approach for Orthopedic Implant Design and Evaluation Through Strain Shielding Analysis.Biomimetics (Basel, Switzerland) · 2025Article
- Understanding the relationship between pore structure and properties of triply periodic minimal surface bone scaffolds.Journal of materials science. Materials in medicine · 2025Review
- TPMS Microarchitectures for Vertical Bone Augmentation and Osteoconduction: An In Vivo Study.Materials (Basel, Switzerland) · 2024Article
- Triply Periodic Minimal Surface-Based Scaffolds for Bone Tissue Engineering: A Mechanical,Tissue engineering. Part A · 2023Article
- Polyether-Ether-Ketone (PEEK) and Its 3D-Printed Quantitate Assessment in Cranial Reconstruction.Journal of functional biomaterials · 2023Article
- Advances in Computational Techniques for Bio-Inspired Cellular Materials in the Field of Biomechanics: Current Trends and Prospects.Materials (Basel, Switzerland) · 2023Review
- Robocasting of Ceramic Fischer-Koch S Scaffolds for Bone Tissue Engineering.Journal of functional biomaterials · 2023Article
- Additively manufactured porous scaffolds by design for treatment of bone defects.Frontiers in bioengineering and biotechnology · 2023Review
- Surface-Modifying Effect of Zwitterionic Polyurethane Oligomers Complexed with Metal Ions on Blood Compatibility.Tissue engineering and regenerative medicine · 2022Article
- Definition, measurement, and function of pore structure dimensions of bioengineered porous bone tissue materials based on additive manufacturing: A review.Frontiers in bioengineering and biotechnology · 2022Review
- PCL strut-like scaffolds appear superior to gyroid in terms of bone regeneration within a long bone large defect: AnFrontiers in bioengineering and biotechnology · 2022Article
- Recent update on craniofacial tissue engineering.Journal of tissue engineeringReview
- Novel 3D printed TPMS scaffolds: microstructure, characteristics and applications in bone regeneration.Journal of tissue engineeringReview
- Meniscus regeneration by 3D printing technologies: Current advances and future perspectives.Journal of tissue engineeringReview
- Freeform 3D printing of vascularized tissues: Challenges and strategies.Journal of tissue engineeringReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three different triply periodic minimal surfaces (TPMS) with three levels of porosity within those of cancellous bone were investigated as potential bone scaffolds. TPMS have emerged as potential designs to resemble the complex mechanical and mass transport properties of bone. Diamond, Schwarz, and Gyroid structures were 3D printed in polylactic acid, a resorbable medical grade material. The 3D printed structures were investigated for printing feasibility, and assessed by morphometric studies. Mechanical properties and permeability investigations resulted in similar values to cancellous bone. The morphometric analyses showed three different patterns of pore distribution: mono-, bi-, and multimodal pores. Subsequently, biological activity investigated with pre-osteoblastic cell lines showed no signs of cytotoxicity, and the scaffolds supported cell proliferation up to 3 weeks. Cell differentiation investigated by alkaline phosphatase showed an improvement for higher porosities and multimodal pore distributions, suggesting a higher dependency on pore distribution and size than the level of interconnectivity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.