Evidence map›Paper›PMID 33224365›Full record

ArticleGastroenterology research2020

A Systematic Literature Review and Meta-Analysis Describing the Prevalence of

Elizabeth Levin-Sparenberg, Lauren C Bylsma, Kimberly Lowe, Laura Sangare, Jon P Fryzek, Dominik D Alexander

Open access · diamondAbstract read
In one paragraph

Article in Gastroenterology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 47 citations in OpenAlex.

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  11. Expert consensus on the optimal management of BRAFAsia-Pacific journal of clinical oncology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Elizabeth Levin-SparenbergEpidstat Institute, Ann Arbor, MI, USA.
Lauren C BylsmaEpidstat Institute, Ann Arbor, MI, USA.
Kimberly LoweAmgen, Inc., 1 Amgen Center Drive, Mailstop D2262, Thousand Oaks, CA 91320, USA.
Laura SangareSimulStat, Portland, OR, USA.
Jon P FryzekEpidstat Institute, Rockville, MD, USA.
Dominik D AlexanderEpidstat Institute, Ann Arbor, MI, USA.
Michigan United · USAmgen (United States) · USInternational Epidemiology Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTumors of the metastatic colorectal cancer (mCRC) patients that are wildtype (WT) for

methodsA systematic literature review was conducted among studies that described the prevalence of

resultsThis systematic review and meta-analysis included 275 studies comprising 77,104 mCRC patients. The summary prevalence estimate was 35.9% for

conclusions

Indexed as

BRAFKRASMeta-analysisMetastatic colorectal cancerNRAS

Identifiers

PMID33224365
PMCPMC7665856
OpenAlexW3107421140

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.