ArticleIranian journal of pharmaceutical research : IJPR2020
Suvorexant, a Dual Orexin Receptor Antagonist, Protected Seizure through Interaction with GABA
Article in Iranian journal of pharmaceutical research : IJPR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 10 citations in OpenAlex.
- Advances and challenges in experimental models of posttraumatic epilepsy for therapeutic interventions.Pharmacological reviews · 2025Review
- Transient targeting of hypothalamic orexin neurons alleviates seizures in a mouse model of epilepsy.Nature communications · 2024Article
- Article
- Sleep fragmentation and decreased REM sleep in a primate model of diurnal cortical seizures.Epilepsy research · 2021Article
- "Adverse event reports of seizure for insomnia medication from 1967 to 2023". The challenge of using hypnotic medication in people with epilepsy.Frontiers in neurologyArticle
- The Effect of Physical Activity on the Orexin and Brain-derived Neurotrophic Factor Expression on the Kindling Model of Epileptic Rats.Basic and clinical neuroscienceArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Orexin can increase neuronal excitability and induce epileptic activity. In this study, the effects of suvorexant (orexin receptor antagonist) on pentylenetetrazol (PTZ) and maximal electroshock (MES)-induced seizure were investigated. Mice were divided into 5 groups of six animals each including normal saline (10 mL/kg), diazepam (2 mg/kg), and suvorexant (50, 100 and 200 mg/kg) groups. In PTZ test, the latency to first minimal clonic seizure (MCS), latency to the first generalized tonic-clonic seizures (GTCS), total duration of seizure and also protection against mortality were evaluated. In MES, the hind limb tonic extension (HLTE) and the protection against mortality were recorded. In order to evaluate the role of GABA
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Registered trials
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