Evidence map›Paper›PMID 33224221›Full record

ArticleIranian journal of pharmaceutical research : IJPR2020

Novel Small Molecules against Two Binding Sites of Wnt2 Protein as potential Drug Candidates for Colorectal Cancer: A Structure Based Virtual Screening Approach.

Hourieh Kalhor, Hamzeh Rahimi, Mohammad Reza Akbari Eidgahi, Ladan Teimoori-Toolabi

Open access · greenAbstract read
In one paragraph

Article in Iranian journal of pharmaceutical research : IJPR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Non-Coding RNA and Frizzled Receptors in Cancer.Frontiers in molecular biosciences · 2021
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Hourieh KalhorDepartment and Biotechnology Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Hamzeh RahimiDepartment of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran.
Mohammad Reza Akbari EidgahiDepartment and Biotechnology Research Center, Semnan University of Medical Sciences, Semnan, Iran.
Ladan Teimoori-ToolabiDepartment of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran.
Pasteur Institute of Iran · IRSemnan University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Wnts are the major ligands responsible for activating Wnt signaling pathway through binding to Frizzled proteins (Fzd) as the receptors. Among these ligands, Wnt2 plays the main role in the tumorigenesis of several human cancers especially colorectal cancer (

Indexed as

CRCMolecular dockingMolecular dynamics simulationsWnt2 proteinWnt signaling pathway

Identifiers

PMID33224221
PMCPMC7667561
OpenAlexW3088709773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.