Evidence map›Paper›PMID 33224153›Full record

ArticleFrontiers in immunology2020

MPEG1/Perforin-2 Haploinsufficiency Associated Polymicrobial Skin Infections and Considerations for Interferon-γ Therapy.

Leidy C Merselis, Shirley Y Jiang, Stanley F Nelson, Hane Lee, Kavitha K Prabaker, Jennifer L Baker, George P Munson, Manish J Butte

Registry-linked trialOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02450851 (Clinical and Genetic Evaluation of Patients With Undiagnosed Disorders Through the Undiagnosed Diseases Network), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02450851 recruitingnot on this map

Clinical and Genetic Evaluation of Patients With Undiagnosed Disorders Through the Undiagnosed Diseases Network

TypeobservationalSponsorNational Human Genome Research Institute (NHGRI)Ran2015 to 2028Enrolled20,000ConditionsGenetic Disease
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Leidy C MerselisUniversity of Miami Miller School of Medicine, Department of Microbiology and Immunology, Miami, FL, United States.
Shirley Y JiangDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, University of California Los Angeles, Los Angeles, CA, United States.
Stanley F NelsonDepartment of Human Genetics, University of California Los Angeles, Los Angeles CA, United States.
Hane LeeDepartment of Human Genetics, University of California Los Angeles, Los Angeles CA, United States.
Kavitha K PrabakerDivision of Infectious Diseases, Department of Medicine, University of California Los Angeles, Los Angeles, CA, United States.
Jennifer L BakerDepartment of Surgery, University of California Los Angeles, Los Angeles, CA, United States.
George P MunsonUniversity of Miami Miller School of Medicine, Department of Microbiology and Immunology, Miami, FL, United States.
Manish J ButteDivision of Immunology, Allergy, and Rheumatology, Department of Pediatrics, University of California Los Angeles, Los Angeles, CA, United States.
University of California, Los Angeles · USUniversity of Miami · US

Funding

UCLA clinical site for the investigation of undiagnosed disordersU01HG007703 · NHGRI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MARTINEZ-AGOSTO, JULIAN, NELSON, STANLEY F. · 2014 to 2022
$10.1M
Resource for Biocomputing Visualization and InformaticsP41GM103311 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIN, THOMAS E · 2012 to 2017
$8.2M
Killing of intracellular bacteria by Perforin-2R01AI110810 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MUNSON, GEORGE PATRICK · 2015 to 2019
$2.1M
Influences of nanomechanical forces on T cellsR01GM110482 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BUTTE, MANISH J · 2014 to 2018
$1.6M
Elucidating Perforin-2 mediated killing mechanisms against pathogenic bacteriaF31AI106290 · NIAID · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MCCORMACK, RYAN MICHAEL · 2013 to 2018
$268k
NHGRI NIH HHS U01 HG007703NIAID NIH HHS F31 AI106290NIAID NIH HHS R01 AI110810NIGMS NIH HHS P41 GM103311NIGMS NIH HHS R01 GM110482
6 · The paper itself

Abstract

Introduction: Macrophage expressed gene 1 ( Case Description: A young adult female patient was evaluated for recurrent abscesses and cellulitis of the breast and demonstrated a heterozygous, rare variant in Conclusions: This case expands the phenotype of

Indexed as

HaploinsufficiencyCandidiasis, CutaneousCoinfectionFemaleGenetic Predisposition to DiseaseHumansImmunity, InnateInterferon-gammaMembrane ProteinsPhagocytesPhenotypePore Forming Cytotoxic ProteinsSkin Diseases, BacterialTreatment OutcomeYoung AdultInterferon-gammaMembrane ProteinsMPEG1 protein, humanperforin 2Pore Forming Cytotoxic Proteinscase reportinterferon gammamembrane attack complexMPEG1 p.Tyr430*perforin-2primary immunodeficiency

Identifiers

PMID33224153
PMCPMC7670069
OpenAlexW3096480092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.