Observational studyFrontiers in endocrinology2020
Excessive Maternal Weight and Diabetes Are Risk Factors for Macrosomia: A Cross-Sectional Study of 42,663 Pregnancies in Uruguay.
Observational study in Frontiers in endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- Adverse perinatal outcomes associated with macrosomia in nulliparous women: A multicenter cohort study.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2026Article
- Prevalence and determinants of macrosomia in low- and middle-income countries: a multilevel analysis of population survey data from 44 nations.Maternal health, neonatology and perinatology · 2025Article
- Biomarkers predicting adverse pregnancy outcomes in women living with obesity: a systematic review and meta-analysis.AJOG global reports · 2025Review
- Pregestational Diabetes Mellitus and Adverse Perinatal Outcomes: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Article
- Assessing the risk factors and establishing multivariable prediction models for singleton macrosomia.Frontiers in medicine · 2025Article
- Position statement of Italian Society of Obesity (SIO): Gestational Obesity.Eating and weight disorders : EWD · 2024Review
- Impact of Pre-Gestational BMI and Gestational Weight Gain on Fetal Development Outcomes in Adolescent Pregnant Women.Journal of clinical medicine · 2024Article
- Evaluating causal influence of maternal educational attainment on offspring birthweight via observational study and Mendelian randomization analyses.SSM - population health · 2024Article
- Prevalence and determinants of fetal macrosomia in Bangladesh.Frontiers in pediatrics · 2024Article
- Impact of anthro-metabolic indices and gestational weight gain on maternal and neonatal outcomes: a prospective observational study.Revista da Associacao Medica Brasileira (1992) · 2024Observational
- Maternal Obesity, Gestational Diabetes, and Fetal Macrosomia: An Incidental or a Mechanistic Relationship?Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- Evolution of Gestational Diabetes Mellitus across Continents in 21st Century.International journal of environmental research and public health · 2022Review
- Insulin Resistance is a Risk Factor for Early Miscarriage and Macrosomia in Patients With Polycystic Ovary Syndrome From the First Embryo Transfer Cycle: A Retrospective Cohort Study.Frontiers in endocrinology · 2022Observational
- Protective Effect of Maternal First-Trimester Low Body Mass Index Against Macrosomia: A 10-Year Cross-Sectional Study.Frontiers in endocrinology · 2022Article
- Association Between Body Mass Index and Female Infertility in the United States: Data from National Health and Nutrition Examination Survey 2013-2018.International journal of general medicine · 2022Article
- Effect of high-fat diet for rats at different stages on glucose and lipid metabolism in offspring and related mechanisms.Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2021Article
- Immigration and Adverse Pregnancy Outcomes in an Italian Free Care Hospital.International journal of women's health · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To evaluate the risk of macrosomia in newborns from women with gestational diabetes, pregestational diabetes, overweight, and obesity in Uruguay in 2012, as well as its association with prolonged pregnancy, maternal age, multiparity, and excessive gestational weight gain (EGWG). Methods: We performed a cross-sectional study of 42,663 pregnant women. The risk of macrosomia was studied using logistic regression. Results: Mean maternal age was 26.7 ± 6.8 years. Pregestational overweight and obesity was present in 20.9% and 10.7% of women, respectively. There were 28.1% and 19.8% of women overweight and obese at the end of the pregnancy, respectively. Furthermore, 0.5% had pregestational diabetes and 8.5% were multiparous. Twenty two percent developed gestational diabetes and 44.9% had EGWG. The prevalence of macrosomia was 7.9%, significantly more prevalent in males (10.0% vs. 5.5%, p<0.005). Univariate analysis showed that obesity and overweight pre-pregnancy, obesity and overweight at the end of pregnancy, EGWG, pregestational diabetes, gestational diabetes, multiparity, prolonged pregnancy, and male newborn were strongly associated with macrosomia (p<0.0001). Maternal age >35 years did not increase the risk of macrosomia. After multiple logistic regression macrosomia was more likely in pre-gestational obese women (OR 1.24; CI 1.07-1.44), overweight women at the end of pregnancy (OR 1.66; CI 1.46-1.87), obese women at the end of pregnancy (OR 2.21; CI 1.90-2.58), women with EGWG (OR 1.78; CI 1.59-1.98), pregestational diabetes (OR 1.75; CI 1.15-2.69), gestational diabetes (OR 1.39; CI 1.25-1.53), prolonged pregnancy (OR 2.67; CI 2.28-3.12), multiparity (OR 1.24; CI 1.04-1.48), and male newborn (OR 1.89; CI 1.72-2.08). Conclusion: Maternal overweight, obesity, EGWG, and gestational diabetes are prevalent in Uruguay, increasing the risk of macrosomia. Efforts to implement strategies to decrease the prevalence of overweight and obesity among women of reproductive age are essential to improve maternal and neonatal outcomes.
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