Evidence map›Paper›PMID 33224024›Full record

ArticleFrontiers in neuroscience2020

Alterations in Degree Centrality and Functional Connectivity in Parkinson's Disease Patients With Freezing of Gait: A Resting-State Functional Magnetic Resonance Imaging Study.

MiaoRan Guo, Yan Ren, HongMei Yu, HuaGuang Yang, ChengHao Cao, YingMei Li, GuoGuang Fan

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PubMed Full text at PMC Publisher
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Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
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32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

MiaoRan GuoDepartment of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.
Yan RenDepartment of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, China.
HongMei YuDepartment of Neurology, The First Affiliated Hospital of China Medical University, Shenyang, China.
HuaGuang YangDepartment of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.
ChengHao CaoDepartment of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.
YingMei LiDepartment of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.
GuoGuang FanDepartment of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFreezing of gait (FOG) is a common disabling motor symptom in Parkinson's disease (PD), but the potential pathogenic mechanisms are still unclear.

methodsA total of 22 patients with PD with FOG (PD-FOG), 28 patients with PD without FOG (PD-nFOG), and 33 healthy controls (HCs) were recruited in this study. Degree centrality (DC)-a graph theory-based measurement of global connectivity at the voxel level by measuring the number of instantaneous functional connections between one region and the rest of the brain-can map brain hubs with high sensitivity, specificity, and reproducibility. DC was used to explore alterations in the centrality of PD-FOG correlated with brain node levels. PD-FOG cognitive network dysfunction was further revealed via a seed-based functional connectivity (FC) analysis. In addition, correlation analyses were carried out between clinical symptoms and acquired connectivity measurement.

resultsCompared to the PD-nFOG group, the PD-FOG group showed remarkably increased DC values in the right middle frontal gyrus (RMFG). There were no significant differences in other gray matter regions. Importantly, the clinical severity of FOG was related to the mean DC values in the RMFG. This brain region served as a seed in secondary seed-based FC analysis, and we further found FC changes in the right precuneus, right inferior frontal gyrus, right superior frontal gyrus (SFG), and cerebellum.

conclusionIncreased RMFG activity and FC network alterations in the middle frontal cortex with the precuneus, inferior, and SFG, and the cerebellum may have great potential in brain dysfunction in PD with FOG.

Indexed as

degree centralityfreezing of gaitfunctional connectivityParkinson’s diseaseResting-state fMRI

Identifiers

PMID33224024
PMCPMC7670067

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.