Evidence map›Paper›PMID 33223572›Full record

ArticleStat2020

Joint estimation of multiple mixed graphical models for pan-cancer network analysis.

Bochao Jia, Faming Liang

Abstract read
In one paragraph

Article in Stat, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bochao JiaEli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46225, USA.
Faming LiangDepartment of Statistics, Purdue University, West Lafayette, 47907, IN, USA.ORCID 0000-0002-1177-5501

Funding

An Imputation-Consistency Algorithm for Biomedical Complex Data AnalysisR01GM126089 · NIGMS · PURDUE UNIVERSITY · PI LIANG, FAMING · 2018 to 2021
$1.2M
Equivalent Partial Correlation Methods for Integrative Genetic Network Analysis R01GM117597 · NIGMS · UNIVERSITY OF FLORIDA · PI LIANG, FAMING · 2015 to 2017
$1.0M
NIGMS NIH HHS R01 GM117597NIGMS NIH HHS R01 GM126089
6 · The paper itself

Abstract

Graphical models have been used in many scientific fields for exploration of conditional independence relationships for a large set of random variables. Although a variety of methods have been proposed in the literature for estimating graphical models with different types of data, none of them is applicable for jointly estimating multiple mixed graphical models. To tackle this problem, we propose a joint mixed learning method. The proposed method is very flexible, which works for various mixed types of data, such as those mixed with Gaussian, multinomial, and Poisson, and also allows people to incorporate domain knowledge into network construction by restricting some links to be included in or excluded from the networks. As an application, the proposed method is applied to pan-cancer network analysis for six types of cancer with data from The Cancer Genome Atlas. To our knowledge, this is the first work for joint estimation of multiple mixed graphical models.

Indexed as

data integrationhybrid Bayesian learninglink restrictionmeta-analysisnodewise screening

Identifiers

PMID33223572
PMCPMC7676750

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.