Evidence map›Paper›PMID 33223513›Full record

ArticleBiomolecules & therapeutics2021

Systematic Target Screening Revealed That Tif302 Could Be an Off-Target of the Antifungal Terbinafine in Fission Yeast.

Sol Lee, Miyoung Nam, Ah-Reum Lee, Jaewoong Lee, Jihye Woo, Nam Sook Kang, Anand Balupuri, Minho Lee, Seon-Young Kim, Hyunju Ro and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules & therapeutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Sol LeeDepartment of New Drug Development, Chungnam National University, Daejeon 34134, Republic of Korea.
Miyoung NamDepartment of New Drug Development, Chungnam National University, Daejeon 34134, Republic of Korea.
Ah-Reum LeeDepartment of New Drug Development, Chungnam National University, Daejeon 34134, Republic of Korea.
Jaewoong LeeDepartment of New Drug Development, Chungnam National University, Daejeon 34134, Republic of Korea.
Jihye WooDepartment of New Drug Development, Chungnam National University, Daejeon 34134, Republic of Korea.
Nam Sook KangDepartment of New Drug Development, Chungnam National University, Daejeon 34134, Republic of Korea.
Anand BalupuriDepartment of New Drug Development, Chungnam National University, Daejeon 34134, Republic of Korea.
Minho LeeDepartment of Life Science, Dongguk University-Seoul, Goyang 10326, Republic of Korea.
Seon-Young KimPersonalized Genomic Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
Hyunju RoDepartment of Biological Science, College of Bioscience & Biotechnology, Chungnam National University, Daejeon 34134, Republic of Korea.
Youn-Woong ChoiKorea United Pharm. Inc., Seoul 06116, Republic of Korea.
Dong-Uk KimRare Disease Research Center, Korea Research Institute of Bioscience & Biotechnology (KRIBB), Daejeon 34141, Republic of Korea.
Kwang-Lae HoeDepartment of New Drug Development, Chungnam National University, Daejeon 34134, Republic of Korea.
Chungnam National University · KRKorea Research Institute of Bioscience and Biotechnology · KRDongguk University · KRKorea Pharma (South Korea) · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We used a heterozygous gene deletion library of fission yeasts comprising all essential and non-essential genes for a microarray screening of target genes of the antifungal terbinafine, which inhibits ergosterol synthesis via the Erg1 enzyme. We identified 14 heterozygous strains corresponding to 10 non-essential [7 ribosomal-protein (RP) coding genes,

Indexed as

AntifungalDrug targetRibosomal proteinSterolTerbinafineTranslation

Identifiers

PMID33223513
PMCPMC7921855
OpenAlexW3110039775

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.