ArticlePsychological medicine2022
Context-specific abnormalities of the central executive network in first-episode psychosis: relationship with cognition.
Article in Psychological medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Targeting Network Imbalance in Schizophrenia: The Application of Temporal Interference Stimulation.Alpha psychiatry · 2026Article
- Alterations of White Matter Structural Brain Network in Children With Sensorineural Hearing Loss: A Graph Theory Analysis for Auditory Sensitivity Period.Neural plasticity · 2026Article
- Neuroimaging features of cognitive impairments in schizophrenia and major depressive disorder.Therapeutic advances in psychopharmacology · 2024Review
- Revisiting Functional Dysconnectivity: a Review of Three Model Frameworks in Schizophrenia.Current neurology and neuroscience reports · 2023Review
- Switching between External and Internal Attention in Hippocampal Networks.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Resting-state functional MRI in treatment-resistant schizophrenia.Frontiers in neuroimaging · 2023Review
- Relationship between plasma clozapine/N-desmethylclozapine and changes in basal forebrain-dorsolateral prefrontal cortex coupling in treatment-resistant schizophrenia.Schizophrenia research · 2022Article
- High-frequency repetitive transcranial magnetic stimulation improves spatial episodic learning and memory performance by regulating brain plasticity in healthy rats.Frontiers in neuroscience · 2022Article
- Is it time to put rest to rest?Trends in cognitive sciences · 2021Review
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCognitive impairments, which contribute to the profound functional deficits observed in psychotic disorders, have found to be associated with abnormalities in trial-level cognitive control. However, neural tasks operate within the context of sustained cognitive states, which can be assessed with 'background connectivity' following the removal of task effects. To date, little is known about the integrity of brain processes supporting the maintenance of a cognitive state in individuals with psychotic disorders. Thus, here we examine background connectivity during executive processing in a cohort of participants with first-episode psychosis (FEP).
methodsThe following fMRI study examined background connectivity of the dorsolateral prefrontal cortex (DLPFC), during working memory engagement in a group of 43 patients with FEP, relative to 35 healthy controls (HC). Findings were also examined in relation to measures of executive function.
resultsThe FEP group relative to HC showed significantly lower background DLPFC connectivity with bilateral superior parietal lobule (SPL) and left inferior parietal lobule. Background connectivity between DLPFC and SPL was also positively associated with overall cognition across all subjects and in our FEP group. In comparison, resting-state frontoparietal connectivity did not differ between groups and was not significantly associated with overall cognition, suggesting that psychosis-related alterations in executive networks only emerged during states of goal-oriented behavior.
conclusionsThese results provide novel evidence indicating while frontoparietal connectivity at rest appears intact in psychosis, when engaged during a cognitive state, it is impaired possibly undermining cognitive control capacities in FEP.
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