ArticleJournal of neuroinflammation2020
Diesel exhaust impairs TREM2 to dysregulate neuroinflammation.
Article in Journal of neuroinflammation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Air pollution, depressive and anxiety disorders, and brain effects: A systematic review.Neurotoxicology · 2022Pooled it
- Effects of Traffic-Related Diesel Exhaust Exposure and Moderate Exercise on Obesity, Metabolic Dysfunction, and Inflammatory Responses in Rats.Metabolites · 2026Article
- DDT exposure induces microglial activation and disease-associated microglial signatures: Relevance to mechanisms of Alzheimer's disease.Neurotoxicology · 2025Article
- Targeting CX3CR1 Signaling Dynamics: A Critical Determinant in the Temporal Regulation of Post-Stroke Neurorepair.Brain sciences · 2025Review
- Air Pollution and Stroke: An Emerging Challenge From Cardio-Cerebrovascular Multimorbidity.Journal of the American Heart Association · 2025Review
- Ecdysterone Alleviates Atherosclerosis by Inhibiting NCF2 and Inhibiting Ferroptosis Mediated by the PI3K/Akt/Nrf2 Pathway.Journal of cellular and molecular medicine · 2025Article
- Dehydroervatamine as a promising novel TREM2 agonist, attenuates neuroinflammation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Neuroinflammation and Brain Health Risks in Veterans Exposed to Burn Pit Toxins.International journal of molecular sciences · 2024Review
- Neuroinflammation is dependent on sex and ovarian hormone presence following acute woodsmoke exposure.Scientific reports · 2024Article
- The bidirectional lung brain-axis of amyloid-β pathology: ozone dysregulates the peri-plaque microenvironment.Brain : a journal of neurology · 2023Article
- Stress Drivers of Glucose Dynamics during Ozone Exposure Measured Using Radiotelemetry in Rats.Environmental health perspectives · 2022Article
- Association between air pollution and CSF sTREM2 in cognitively normal older adults: The CABLE study.Annals of clinical and translational neurology · 2022Article
- PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer's disease.Genome medicine · 2022Article
- Adrenergic and Glucocorticoid Receptors in the Pulmonary Health Effects of Air Pollution.Toxics · 2021Review
- The Use of Standardized Diesel Exhaust Particles in Alzheimer's Disease Research.Journal of Alzheimer's disease : JAD · 2021Article
- Neurovascular Alterations in Vascular Dementia: Emphasis on Risk Factors.Frontiers in aging neuroscience · 2021Article
- Air Pollutant impacts on the brain and neuroendocrine system with implications for peripheral organs: a perspective.Inhalation toxicologyReview
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAir pollution has been linked to neurodegenerative diseases, including Alzheimer's disease (AD), and the underlying neuroimmune mechanisms remain poorly understood. TREM2 is a myeloid cell membrane receptor that is a key regulator of disease-associated microglia (DAM) cells, where loss-of-function TREM2 mutations are associated with an increased risk of AD. At present, the basic function of TREM2 in neuroinflammation is a point of controversy. Further, the impact of air pollution on TREM2 and the DAM phenotype is largely unknown. Using diesel exhaust (DE) as a model of urban air pollution exposure, we sought to address its impact on TREM2 expression, the DAM phenotype, the association of microglia with the neurovasculature, and the role of TREM2 in DE-induced neuroinflammation.
methodsWYK rats were exposed for 4 weeks to DE (0, 50, 150, 500 μg/m
resultsRats exposed to DE exhibited inverted-U patterns of Trem2 mRNA expression in the hippocampus and frontal cortex, while TREM2 protein was globally diminished, indicating impaired TREM2 expression. Analysis of DAM markers Cx3Cr1, Lyz2, and Lpl in the frontal cortex and hippocampus showed inverted-U patterns of expression as well, supporting dysregulation of the DAM phenotype. Further, microglial-vessel association decreased with DE inhalation in a dose-dependent manner. Mechanistically, intratracheal administration of DEP increased Tnf (TNFα), Ncf1 (p47
conclusionsCollectively, these findings reveal a novel role for TREM2 in how air pollution regulates neuroinflammation and provides much needed insight into the potential mechanisms linking urban air pollution to AD.
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Registered trials
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