ArticleJournal of the American Heart Association2020
Adverse Trends in Premature Cardiometabolic Mortality in the United States, 1999 to 2018.
Article in Journal of the American Heart Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Electronic Health Record-Driven Approaches in Primary Care to Strengthen Hypertension Management Among Racial and Ethnic Minoritized Groups in the United States: Systematic Review.Journal of medical Internet research · 2023Pooled it
- The weight of timing: childhood-to-adulthood body mass index trajectories and the reversibility of coronary heart disease risk.Journal of thoracic disease · 2026Article
- Article
- Longitudinal Changes in Coronary Artery Calcium Distribution and Atherosclerotic Cardiovascular Disease Risk.Journal of the American Heart Association · 2026Article
- Article
- Skin tone - a marker of bias known as colorism - in relation to sleep health among African American women.SSM - population health · 2025Article
- Unraveling trends and disparities in acute myocardial infarction-related mortality among adult cancer patients: A nationwide CDC-WONDER analysis (1999-2020).International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Changing trends in myocardial infarction mortality among young adults in the United States: a 25-year analysis of disparities and the COVID-19 impact.Archives of medical sciences. Atherosclerotic diseases · 2025Article
- Article
- Traditional and non-traditional cardiovascular risk factor profiles in young patients with coronary artery disease.American heart journal plus : cardiology research and practice · 2024Article
- Midlife diseases of despair and cardiometabolic risk: testing shared origins in adolescent psychopathology.Psychological medicine · 2024Article
- Association of Socioeconomic Status With Life's Essential 8 in the National Health and Nutrition Examination Survey: Effect Modification by Sex.Journal of the American Heart Association · 2024Article
- Low educational attainment is associated with higher all-cause and cardiovascular mortality in the United States adult population.BMC public health · 2023Article
- The rise and fall of tobacco smoking and associated rise and fall of coronary atherosclerosis the lethal role of tobacco.Frontiers in cardiovascular medicine · 2023Review
- A Pilot Study About the Role of PANoptosis-Based Genes in Atherosclerosis Development.Journal of inflammation research · 2023Article
- Eradicating Atherosclerosis: Should We Start Statins at Younger Ages and at Lower LDL-Cs.Current cardiology reports · 2022Review
- Predictive Utility of a Validated Polygenic Risk Score for Long-Term Risk of Coronary Heart Disease in Young and Middle-Aged Adults.Circulation · 2022Article
- Age at Diagnosis of CVDs by Race and Ethnicity in the U.S., 2011 to 2020.JACC. Advances · 2022Article
- Trends in Premature Mortality From Acute Myocardial Infarction in the United States, 1999 to 2019.Journal of the American Heart Association · 2022Article
- Increased Mortality Trends in Patients With Chronic Non-communicable Diseases and Comorbid Hypertension in the United States, 2000-2019.Frontiers in public health · 2022Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Background Life expectancy in the United States has recently declined, in part attributable to premature cardiometabolic mortality. We characterized national trends in premature cardiometabolic mortality, overall, and by race-sex groups. Methods and Results Using death certificates from the Centers for Disease Control and Prevention's Wide-Ranging Online Data for Epidemiologic Research, we quantified premature deaths (<65 years of age) from heart disease, cerebrovascular disease, and diabetes mellitus from 1999 to 2018. We calculated age-adjusted mortality rates (AAMRs) and years of potential life lost (YPLL) from each cardiometabolic cause occurring at <65 years of age. We used Joinpoint regression to identify an inflection point in overall cardiometabolic AAMR trends. Average annual percent change in AAMRs and YPLL was quantified before and after the identified inflection point. From 1999 to 2018, annual premature deaths from heart disease (117 880 to 128 832), cerebrovascular disease (18 765 to 20 565), and diabetes mellitus (16 553 to 24 758) as an underlying cause of death increased. By 2018, 19.7% of all heart disease deaths, 13.9% of all cerebrovascular disease deaths, and 29.1% of all diabetes mellitus deaths were premature. AAMRs and YPLL from heart disease and cerebrovascular disease declined until the inflection point identified in 2011, then remained unchanged through 2018. Conversely, AAMRs and YPLL from diabetes mellitus did not change through 2011, then increased through 2018. Black men and women had higher AAMRs and greater YPLL for each cardiometabolic cause compared with White men and women, respectively. Conclusions Over one-fifth of cardiometabolic deaths occurred at <65 years of age. Recent stagnation in cardiometabolic AAMRs and YPLL are compounded by persistent racial disparities.
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