Evidence map›Paper›PMID 33222517›Full record

ArticleBioTechniques2021

Generation of genetically tailored porcine liver cancer cells by CRISPR/Cas9 editing.

Lobna Elkhadragy, Maureen R Regan, William M Totura, Kimia Dasteh Goli, Shovik Patel, Kelly Garcia, Matthew Stewart, Lawrence B Schook, Ron C Gaba, Kyle M Schachtschneider

Open access · goldAbstract read
In one paragraph

Article in BioTechniques, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Pigs: Large Animal Preclinical Cancer Models.World journal of oncology · 2024
    Review
  5. Review
  6. Article
  7. Review
  8. Effect of CRISPR Knockout ofFrontiers in oncology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Lobna ElkhadragyDepartment of Radiology, University of Illinois at Chicago, Chicago, IL 60612, USA.ORCID 0000-0001-8956-298X
Maureen R ReganDepartment of Biochemistry & Molecular Genetics, University of Illinois at Chicago, Chicago, IL 60607, USA.
William M ToturaDepartment of Radiology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Kimia Dasteh GoliDepartment of Radiology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Shovik PatelDepartment of Animal Sciences, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
Kelly GarciaBiological Research Laboratory, University of Illinois at Chicago, Chicago, IL 60612, USA.
Matthew StewartDepartment of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, IL 61802, USA.
Lawrence B SchookDepartment of Radiology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Ron C GabaDepartment of Radiology, University of Illinois at Chicago, Chicago, IL 60612, USA.
Kyle M SchachtschneiderDepartment of Radiology, University of Illinois at Chicago, Chicago, IL 60612, USA.
University of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · US

Funding

Implications of Driver Mutations for Progression of Hepatocellular CarcinomaR21CA219461 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI GABA, RON C, SCHACHTSCHNEIDER, KYLE · 2019 to 2020
$382k
NCI NIH HHS R21 CA219461
6 · The paper itself

Abstract

Pigs provide a valuable large animal model for several diseases due to their similarity with humans in anatomy, physiology, genetics and drug metabolism. We recently generated a porcine model for

Indexed as

Carcinoma, HepatocellularCRISPR-Cas SystemsLiver NeoplasmsAnimalsCell LineGene EditingSwineCRISPR/Cas9gene editinggene knockouthepatocellular carcinomalarge animal modelliver cancerporcine cells

Identifiers

PMID33222517
PMCPMC7852845
OpenAlexW3107661460

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.