ArticleEthnicity & health2022
Racial differences in the association of accelerated aging with future cardiovascular events and all-cause mortality: the coronary artery risk development in young adults study, 2007-2018.
Article in Ethnicity & health, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Molecular markers, mechanisms and metrics of biological aging: a scoping review.Frontiers in aging · 2026Review
- Racial and Social Inequities in Weathering: the ELSA-Brasil Cohort.Journal of racial and ethnic health disparities · 2025Article
- Biological Age as a Predictor of Arterial Stiffness in Young and Early Midlife Black and White Women.American journal of hypertension · 2025Article
- Construction and validation of a DNN-based biological age and its influencing factors in the China Kadoorie Biobank.GeroScience · 2025Article
- Measuring the Interrelationships Between Cognitive Performance, Race/Ethnicity, Discrimination, Health Behaviors, and Physiological Dysregulation: A Path Analysis of the Multi-Ethnic Study of Atherosclerosis.Journal of aging and health · 2025Article
- Clinical biomarker-based biological age predicts deaths in Brazilian adults: the ELSA-Brasil study.GeroScience · 2024Article
- A Comparison of 5 Measures of Accelerated Biological Aging and Their Association With Incident Cardiovascular Disease: The CARDIA Study.Journal of the American Heart Association · 2024Article
- Physiological Dysregulation Proceeds and Predicts Health Outcomes Similarly in Chinese and Western Populations.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- The Association Between Grandchild Care and Biological Aging Among Middle-Aged and Older Adults in China.Innovation in aging · 2024Article
- Association of Socioeconomic Status With Life's Essential 8 Varies by Race and Ethnicity.Journal of the American Heart Association · 2023Article
- Navigating Black Aging: The Biological Consequences of Stress and Depression.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- A cross-sectional analysis of racial differences in accelerated aging and cognitive function among patients with atrial fibrillation: The SAGE-AF study: Forrester, Accelerated aging and cognitive function.EClinicalMedicine · 2021Article
- The Coronary Artery Risk Development In Young Adults (CARDIA) Study: JACC Focus Seminar 8/8.Journal of the American College of Cardiology · 2021Review
- Accelerated aging: A marker for social factors resulting in cardiovascular events?SSM - population health · 2021Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectiveVariability of Cardiovascular disease (CVD) risk, including racial difference, is not fully accounted for by the variability of traditional CVD risk factors. We used a multiple biomarker model as a framework to explore known racial differences in CVD burden.
designWe measured associations between accelerated aging (AccA) measured by a combination of biomarkers, and cardiovascular morbidity and all-cause mortality using data from the Coronary Artery Risk Development in Young Adults study (CARDIA). AccA was defined as the difference between biological age, calculated using biomarkers with the Klemera and Doubal method, and chronological age. Using logistic regression, we assessed overall and race-specific associations between AccA, CVD, and all-cause mortality.
resultsAmong our cohort of 2959 Black or White middle-aged adults, after adjustment, a one-year increase in AccA was associated with increased odds of CVD (Odds Ratio (OR) = 1.04; 95% CI: 1.02, 1.06), stroke (OR = 1.12; 95% CI: 1.07, 1.17), and all-cause mortality (OR = 1.05; 95% CI: 1.02, 1.08). We did not find significant overall racial differences, but we did find race by sex differences where Black men differed markedly from White men in the strength of association with CVD (OR = 1.06, 95% CI: 1.01, 1.12).
conclusionsWe provide evidence that AccA is associated with future CVD.
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