Evidence map›Paper›PMID 33222060›Full record

SynthesisJournal of autism and developmental disorders2021

The Neurobiology of Semantic Processing in Autism Spectrum Disorder: An Activation Likelihood Estimation Analysis.

Lee Phan, Alina Tariq, Garbo Lam, Elizabeth W Pang, Claude Alain

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Journal of autism and developmental disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Lee PhanInstitute of Medical Science, University of Toronto, Toronto, ON, Canada. lee.phan@mail.utoronto.ca.ORCID http://orcid.org/0000-0001-8183-0265
Alina TariqNeuroscience and Mental Health, SickKids Research Institute/Hospital for Sick Children, Toronto, ON, Canada.
Garbo LamNeuroscience and Mental Health, SickKids Research Institute/Hospital for Sick Children, Toronto, ON, Canada.
Elizabeth W PangInstitute of Medical Science, University of Toronto, Toronto, ON, Canada.
Claude AlainRotman Research Institute, Baycrest Health Centre, Toronto, ON, Canada.
University of Toronto · CASickKids Foundation · CAUniversity of British Columbia · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Semantic processing impairments are present in a proportion of individuals with autism spectrum disorder (ASD). Despite the numerous imaging studies investigating this language domain in ASD, there is a lack of consensus regarding the brain structures showing abnormal pattern of activity. This meta-analysis aimed to identify neural activation patterns present during semantic processing in ASD. Findings reveal activation of areas associated with semantic processing and executive functions in ASD. However, the activation was less concise in comparison to controls and there was less activation in the right hemisphere and in areas associated with executive functions. This provides strong support for impaired semantic processing in ASD that is consistently associated with abnormal patterns of neural activity in the semantic network.

Indexed as

Autism Spectrum DisorderSemanticsBrainBrain MappingHumansLikelihood FunctionsMagnetic Resonance ImagingActivation likelihood estimationAutism spectrum disorderFunctional magnetic resonance imaging (fMRI)Left inferior frontal gyrusSemantic processing

Identifiers

PMID33222060
OpenAlexW3107071125

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.