Evidence map›Paper›PMID 33222051›Full record

ArticleEuropean journal of epidemiology2021

The Malmö Offspring Study (MOS): design, methods and first results.

Louise Brunkwall, Daniel Jönsson, Ulrika Ericson, Sophie Hellstrand, Cecilia Kennbäck, Gerd Östling, Amra Jujic, Olle Melander, Gunnar Engström, Jan Nilsson and 5 more

Abstract read
In one paragraph

Article in European journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Trial
  2. Article
  3. Nocturnal melatonin secretion and risk of type 2 diabetes: a prospective cohort study.The Journal of clinical endocrinology and metabolism · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Pain, Stress and Mental Well-Being Over Three Generations.European journal of pain (London, England) · 2025
    Observational
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Observational
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Louise BrunkwallDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Daniel JönssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Ulrika EricsonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Sophie HellstrandDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Cecilia KennbäckDepartment of Internal Medicine, Skane University Hospital, Jan Waldenströms gata 15, 5th floor, 20502, Malmö, Sweden.
Gerd ÖstlingDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Amra JujicDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Olle MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Gunnar EngströmDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Jan NilssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Bodil OhlssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Björn KlingeFaculty of Dentistry, Malmö University, Malmö, Sweden.
Marju Orho-MelanderDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Margaretha PerssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden.
Peter M NilssonDepartment of Clinical Sciences, Lund University, Malmö, Sweden. peter.nilsson@med.lu.se.ORCID http://orcid.org/0000-0002-5652-8459

Funding

European Research Council 885003Hjärt-Lungfonden 2015-0427Vetenskapsrådet 521-2013-2756
6 · The paper itself

Abstract

As cardio metabolic disease manifestations tend to cluster in families there is a need to better understand the underlying mechanisms in order to further develop preventive strategies. In fact, genetic markers used in genetic risk scores, important as they are, will not be able alone to explain these family clusters. Therefore, the search goes on for the so called missing heritability to better explain these associations. Shared lifestyle and social conditions in families, but also early life influences may be of importance. Gene-environmental interactions should be explored. In recent years interest has grown for the role of diet-microbiota associations, as microbiota patterns may be shared by family members. In the Malmö Offspring Study that started in 2013, we have so far been able to examine about 4700 subjects (18-71 years) representing children and grandchildren of index subjects from the first generation, examined in the Malmö Diet Cancer Study during 1991 to 1996. This will provide rich data and opportunities to analyse family traits of chronic disease across three generations. We will provide extensive genotyping and phenotyping including cardiovascular and respiratory function, as well as markers of glucose metabolism. In addition, also cognitive function will be assessed. A 4-day online dietary recall will be conducted and gut as well as oral microbiota analysed. The ambition is to provide one of the first large-scale European family studies with individual data across three generations, which could deepen our knowledge about the role of family traits for chronic disease and its underlying mechanisms.

Indexed as

DietLife StyleMetabolic SyndromeMicrobiotaAdolescentAdultAgedCardiometabolic Risk FactorsChronic DiseaseExerciseFamilyFemaleGene-Environment InteractionHumansMaleMiddle AgedCardio metabolicDietFamilyMicrobiotaOffspringVascular

Identifiers

PMID33222051
PMCPMC7847466

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.