Evidence map›Paper›PMID 33222048›Full record

ArticleInternational journal of hematology2021

Virus-infected peripheral blood plasmablasts in a patient with severe fever with thrombocytopenia syndrome.

Toru Takahashi, Kaori Sano, Tadaki Suzuki, Takuro Matsumura, Kohei Sakai, Takayuki Tominaga, Yuko Sato, Harutaka Katano, Hideki Hasegawa

Abstract readCase Reports
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In one paragraph

Article in International journal of hematology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.1field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Toru Takahashi *Department of Hematology, Yamaguchi Prefectural Grand Medical Center, 10077 Osaki, Hofu, Yamaguchi, 747-8511, Japan. ttakahashi-yu@umin.ac.jp.ORCID http://orcid.org/0000-0001-5912-0208
Kaori Sano *Department of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Tadaki SuzukiDepartment of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Takuro MatsumuraDepartment of Hematology, Yamaguchi Prefectural Grand Medical Center, 10077 Osaki, Hofu, Yamaguchi, 747-8511, Japan.
Kohei SakaiDepartment of Hematology, Yamaguchi Prefectural Grand Medical Center, 10077 Osaki, Hofu, Yamaguchi, 747-8511, Japan.
Takayuki TominagaDepartment of Hematology, Yamaguchi Prefectural Grand Medical Center, 10077 Osaki, Hofu, Yamaguchi, 747-8511, Japan.
Yuko SatoDepartment of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Harutaka KatanoDepartment of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
Hideki HasegawaDepartment of Pathology, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku, Tokyo, 162-8640, Japan.
National Institute of Infectious Diseases · JPYamaguchi Prefecture Central Hospital · JP

Funding

Japan Agency for Medical Research and Development JP19fk0108081Japan Agency for Medical Research and Development JP19fk0108104Japan Agency for Medical Research and Development JP19fm0208002
6 · The paper itself

Abstract

Severe fever with thrombocytopenia syndrome (SFTS) is a tick-borne viral hemorrhagic disease with a high fatality rate. It is caused by the SFTS virus and is endemic in East Asian countries such as China, South Korea, and Japan. Previous studies have shown that plasmablasts appear transiently in peripheral blood during the acute phase of SFTS, but do not specify the characteristics of these plasmablasts. In this report, we describe the features of peripheral blood plasmablasts in a patient with SFTS. Immunohistochemical and immunofluorescence staining detected a small number of atypical lymphocytes expressing the SFTS virus antigen among peripheral leukocytes in a blood sample. The phenotype of the virus-infected cells was CD27+, CD38+, MUM1+, and CD138+, which is consistent with that of plasmablasts. This novel study demonstrates that plasmablasts in the peripheral blood of patients with SFTS are targets of the SFTS virus.

Indexed as

ADP-ribosyl Cyclase 1AgedAnimalsAntigens, ViralBites and StingsCatsHumansImmunophenotypingInterferon Regulatory Factor-4Interferon Regulatory FactorsMaleMembrane GlycoproteinsPhlebovirusPlasma CellsPrecursor Cells, B-LymphoidSevere Fever with Thrombocytopenia SyndromeADP-ribosyl Cyclase 1Antigens, ViralCD38 protein, humanInterferon Regulatory Factor-4Interferon Regulatory FactorsMembrane GlycoproteinsSDC1 protein, humanSyndecan-1Tumor Necrosis Factor Receptor Superfamily, Member 7PlasmablastsSevere fever with thrombocytopenia syndromeSFTS virusTick-borne infectionViral hemorrhagic fever

Identifiers

PMID33222048
OpenAlexW3108014997

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.