SynthesisInteractive cardiovascular and thoracic surgery2021
Mitral valve surgery after a failed MitraClip procedure.
Synthesis in Interactive cardiovascular and thoracic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Transcatheter management of residual mitral regurgitation after transcatheter edge-to-edge repair: a systematic review.Cardiovascular intervention and therapeutics · 2025Pooled it
- Edge-to-edge percutaneous mitral repair for functional ischaemic and non-ischaemic mitral regurgitation: a systematic review and meta-analysis.ESC heart failure · 2022Pooled it
- Surgical repair for a single leaflet device attachment due to a gripper failure from the MitraClip main frame: a case report.European heart journal. Case reports · 2025Article
- Double Valve Repair After a Failed Transcatheter Edge-to-Edge Repair and Previous Valve-Sparing Root Replacement.JACC. Case reports · 2025Article
- Electrosurgical Laceration and Stabilization of Clip Followed by Transapical Mitral Valve Replacement after Failed Transcatheter Edge-to-Edge Mitral Valve Repair: A Promising Alternative to Surgery.Interdisciplinary cardiovascular and thoracic surgery · 2025Article
- Transcatheter mitral valve implantation using TENDYNE valve for the treatment of residual severe mitral regurgitation post-transcatheter mitral valve edge-to-edge repair: a case report.European heart journal. Case reports · 2024Article
- Surgical outcomes of patients at prohibitive risk who are reconsidered for surgery.JTCVS open · 2023Article
- Contemporary outcomes of mitral valve repair for degenerative disease in the era of increased penetrance of percutaneous mitral valve technology.JTCVS open · 2023Article
- Mitral valve surgery after failed transcatheter edge-to-edge repair.JTCVS techniques · 2022Article
- Minimally invasive mitral valve surgery after failed transcatheter mitral valve repair in an intermediate-risk cohort.Interactive cardiovascular and thoracic surgery · 2022Article
- Clinical Impact of Computational Heart Valve Models.Materials (Basel, Switzerland) · 2022Review
- Minimally invasive mitral valve replacement after transcatheter edge-to-edge repair.Journal of surgical case reports · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesAmong patients undergoing transcatheter mitral valve repair with the MitraClip device, a relevant proportion (2-6%) requires open mitral valve surgery within 1 year after unsuccessful clip implantation. The goal of this review is to pool data from different reports to provide a comprehensive overview of mitral valve surgery outcomes after the MitraClip procedure and estimate in-hospital and follow-up mortality.
methodsAll published clinical studies reporting on surgical intervention for a failed MitraClip procedure were evaluated for inclusion in this meta-analysis. The primary study outcome was in-hospital mortality. Secondary outcomes were in-hospital adverse events and follow-up mortality. Pooled estimate rates and 95% confidence intervals (CIs) of study outcomes were calculated using a DerSimionian-Laird binary random-effects model. To assess heterogeneity across studies, we used the Cochrane Q statistic to compute I2 values.
resultsOverall, 20 reports were included, comprising 172 patients. Mean age was 70.5 years (95% CI 67.2-73.7 years). The underlying mitral valve disease was functional mitral regurgitation in 50% and degenerative mitral regurgitation in 49% of cases. The indication for surgery was persistent or recurrent mitral regurgitation (grade >2) in 93% of patients, whereas 6% of patients presented with mitral stenosis. At the time of the operation, 80% of patients presented in New York Heart Association functional class III-IV. Despite favourable intraoperative results, in-hospital mortality was 15%. The rate of periprocedural cerebrovascular accidents was 6%. At a mean follow-up of 12 months, all-cause death was 26.5%. Mitral valve replacement was most commonly required because the possibility of valve repair was jeopardized, likely due to severe valve injury after clip implantation.
conclusionsSurgical intervention after failed transcatheter mitral valve intervention is burdened by high in-hospital and 1-year mortality, which reflects reflecting the high-risk baseline profile of the patients. Mitral valve replacement is usually required due to leaflet injury.
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