ArticleInteractive cardiovascular and thoracic surgery2021
Heart transplant outcomes in patients with mechanical circulatory support: cold storage versus normothermic perfusion organ preservation.
Article in Interactive cardiovascular and thoracic surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Ex vivo heart perfusion: an updated systematic review.Heart failure reviews · 2024Pooled it
- Optimal coronary flow rates for preservation of function during normothermic ex situ heart perfusion.The Journal of thoracic and cardiovascular surgery · 2026Article
- Exercise capacity after mechanical circulatory support compared to heart transplant in advanced heart failure.JHLT open · 2026Article
- Introduction of ex vivo perfusion of extended-criteria donor hearts in a single center in Asia.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2025Article
- Clinical Outcomes of Machine Perfusion and Temperature Control Systems in Heart Transplantation: Where We Stand.Journal of clinical medicine · 2025Review
- The Feasibility of a Beating-Heart Transplant From Brain-Dead Donors.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Ex vivo rat heart normothermic perfusion with intermittent low flow and triiodothyronine.Frontiers in cardiovascular medicine · 2025Article
- European Society of Organ Transplantation (ESOT) Consensus Statement on Machine Perfusion in Cardiothoracic Transplant.Transplant international : official journal of the European Society for Organ Transplantation · 2024Review
- Pre-Treatment of Transplant Donors with Hydrogen Sulfide to Protect against Warm and Cold Ischemia-Reperfusion Injury in Kidney and Other Transplantable Solid Organs.International journal of molecular sciences · 2023Review
- Heart Transplantation in High-Risk Recipients Employing Donor Marginal Grafts Preserved WithTransplant international : official journal of the European Society for Organ Transplantation · 2023Article
- Graft preservation in heart transplantation: current approaches.Frontiers in cardiovascular medicine · 2023Review
- Strategies for Expanding Donors Pool in Heart Transplantation.Reviews in cardiovascular medicine · 2022Review
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPatients with mechanical circulatory support bridged to a heart transplant (HTx) are at higher risk of postoperative graft dysfunction. In this subset, a mode of graft preservation that shortens graft ischaemia should be beneficial.
methodsThe outcomes of 38 patients on mechanical circulatory support (extracorporeal life support, left ventricular assist device and biventricular assist device) who received a HTx between 2015 and 2020 were analysed according to the method of graft preservation: cold storage (CS) group, 24 (63%) or ex vivo perfusion (EVP) group, 14 (37%).
resultsThe median age was 57 (range 30-73) vs 64 (35-75) years (P = 0.10); 88% were men (P = 0.28); extracorporeal life support was more frequent in the CS group (54% vs 36%; P = 0.27) versus left ventricular and biventricular assist devices in the EVP group (46% vs 64%; P = 0.27). Clamping time was shorter in the EVP group (P < 0.001) and ischaemic time >4 h was higher in the CS group (P = 0.01). Thirty-day mortality was 13% (0-27%) in the CS group and 0% (P = 0.28) in the EVP group. A significantly lower primary graft failure [7% (0-23%) vs 42% (20-63%); P = 0.03] was observed in the EVP group. Survival at 1 year was 79 ± 8% (63-95%) in the CS group and 84 ± 10% (64-104%) in the EVP group (P = 0.95).
conclusionsOur results support the use of ex vivo graft perfusion in patients on mechanical circulatory support as a bridge to a HTx. This technique, by shortening graft ischaemic time, seems to improve post-HTx outcomes.
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