ArticleInternational journal of epidemiology2021
Metabolic profiles of socio-economic position: a multi-cohort analysis.
Article in International journal of epidemiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
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Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 76 citations in OpenAlex.
- Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study.BMC medicine · 2023Pooled it
- Determinants of the plasma metabolome: cross-sectional and longitudinal associations over six years in the NESDA cohort.EBioMedicine · 2026Article
- Metabolomic levels mediate the link between socioeconomic factors and changes in declarative memory in women with and without HIV.Brain, behavior, & immunity - health · 2026Article
- Individual and neighborhood socioeconomic inequality and the risk of dementia: A 14-year follow-up study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Serum metabolomic profiles associated with psychoneurological symptoms in women with early-stage breast cancer over one year.Frontiers in oncology · 2026Article
- Effects of Exposure to Ambient Air Pollution on Human Metabolome in Patients with Coronary Artery Disease.Environmental science & technology · 2025Article
- Genetic architecture and analysis practices of circulating metabolites in the NHLBI Trans-Omics for Precision Medicine Program.American journal of human genetics · 2025Article
- Causal inference in multi-cohort studies using the target trial framework to identify and minimize sources of bias.American journal of epidemiology · 2025Article
- Differential extracellular matrix proteomic signatures in colorectal tumors from Appalachian and non-Appalachian patients.Oncology letters · 2025Article
- Metabolic dysfunction over a life course key to healthy ageing inequality.Aging clinical and experimental research · 2025Review
- Sex-specific socioeconomic inequalities in trajectories of anthropometry, blood pressure, and blood-based biomarkers from birth to 18 years: a prospective cohort study.European journal of public health · 2025Article
- Biological embodiment of educational attainment and future risk of breast cancer: findings from a French prospective cohort.BMJ open · 2025Article
- Article
- Pathways From Socioeconomic Factors to Major Cardiovascular Events Among Postmenopausal Veteran and Nonveteran Women: Findings From the Women's Health Initiative.Journal of the American Heart Association · 2024Article
- Sources of variation in the serum metabolome of female participants of the HUNT2 study.Communications biology · 2024Article
- Factors Associated with the Practice of Low-Carb and Low-Fat Diets among Participants of the Longitudinal Study of Adult Health (ELSA-Brasil).Nutrients · 2024Article
- Longitudinal associations of an exposome score with serum metabolites from childhood to adolescence.Communications biology · 2024Article
- Genetic and biological drivers of prostate cancer disparities in Black men.Nature reviews. Urology · 2024Review
- Social inequalities in pregnancy metabolic profile: findings from the multi-ethnic Born in Bradford cohort study.BMC pregnancy and childbirth · 2024Article
- Article
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Authors and funding
29 authors at 12 institutions in 4 countries.
Funding
Abstract
backgroundLow socio-economic position (SEP) is a risk factor for multiple health outcomes, but its molecular imprints in the body remain unclear.
methodsWe examined SEP as a determinant of serum nuclear magnetic resonance metabolic profiles in ∼30 000 adults and 4000 children across 10 UK and Finnish cohort studies.
resultsIn risk-factor-adjusted analysis of 233 metabolic measures, low educational attainment was associated with 37 measures including higher levels of triglycerides in small high-density lipoproteins (HDL) and lower levels of docosahexaenoic acid (DHA), omega-3 fatty acids, apolipoprotein A1, large and very large HDL particles (including levels of their respective lipid constituents) and cholesterol measures across different density lipoproteins. Among adults whose father worked in manual occupations, associations with apolipoprotein A1, large and very large HDL particles and HDL-2 cholesterol remained after adjustment for SEP in later life. Among manual workers, levels of glutamine were higher compared with non-manual workers. All three indicators of low SEP were associated with lower DHA, omega-3 fatty acids and HDL diameter. At all ages, children of manual workers had lower levels of DHA as a proportion of total fatty acids.
conclusionsOur work indicates that social and economic factors have a measurable impact on human physiology. Lower SEP was independently associated with a generally unfavourable metabolic profile, consistent across ages and cohorts. The metabolites we found to be associated with SEP, including DHA, are known to predict cardiovascular disease and cognitive decline in later life and may contribute to health inequalities.
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