Evidence map›Paper›PMID 33221757›Full record

SynthesisAging2020

Incidence of cerebrovascular disease as a comorbidity in patients with COVID-19: A meta-analysis.

Jun Zhang, Haili Wang, Min Wei, Hengzhu Zhang, Boming Xia, Xingdong Wang, Yunlong Pei, Lun Dong, Yuping Li

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jun ZhangDepartment of Clinical Medicine, Dalian Medical University, Dalian 116044, Liaoning, China.
Haili WangDepartment of Clinical Medicine, Dalian Medical University, Dalian 116044, Liaoning, China.
Min WeiDepartment of Neurosurgery, Clinical Medical College of Yangzhou University, Yangzhou 225001, Jiangsu, China.
Hengzhu ZhangDepartment of Neurosurgery, Clinical Medical College of Yangzhou University, Yangzhou 225001, Jiangsu, China.
Boming XiaDepartment of Emergency Medicine, Zhejiang University School of Medicine, Hangzhou 310016, Zhejiang, China.
Xingdong WangDepartment of Neurosurgery, Clinical Medical College of Yangzhou University, Yangzhou 225001, Jiangsu, China.
Yunlong PeiDepartment of Clinical Medicine, Dalian Medical University, Dalian 116044, Liaoning, China.
Lun DongDepartment of Neurosurgery, Clinical Medical College of Yangzhou University, Yangzhou 225001, Jiangsu, China.
Yuping LiDepartment of Neurosurgery, Clinical Medical College of Yangzhou University, Yangzhou 225001, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is essential to know whether COVID-19 patients have a history of cerebrovascular disease, as it may be predictive of prognosis and useful for allocation of limited medical resources. This meta-analysis was performed to assess the incidence of cerebrovascular disease as a comorbidity in COVID-19 patients. The PubMed, Cochrane Library, Embase, CNKI, WFSD, and VIP databases were systematically searched. The pooled analysis of relevant data was conducted using RevMan 5.3 software. The primary outcome was incidence of cerebrovascular disease as a comorbidity. Forty-seven studies involving 16,143 COVID-19 patients were included in this analysis. The incidences of a history of cerebrovascular disease and hypertension in COVID-19 patients were estimated to be 3.0% (95% CI, 2.0%-4.0%; P<0.00001) and 23.0% (95% CI, 16.0%-29.0%; P<0.00001), respectively. The incidence of dizziness/headache as the first symptom in COVID-19 patients was estimated to be 14.0% (95% CI, 8.0%-20.0%; P<0.00001). Subgroup analyses indicated that country, sex ratio, and sample size are potential influencing factors affecting the incidences of cerebrovascular disease, hypertension, and dizziness/headache. These findings suggest that cerebrovascular disease is an underlying comorbidity among patients with COVID-19. In addition, patients experiencing dizziness/headache as the first symptom of COVID-19 should receive a neurological examination.

Indexed as

SARS-CoV-2Cerebrovascular DisordersComorbidityCOVID-19HumansHypertensionIncidenceMortalityPatient Outcome AssessmentPrognosisPublication BiasRisk AssessmentRisk Factorscerebrovascular diseasescomorbidityCOVID-19meta-analysis

Identifiers

PMID33221757
PMCPMC7762481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.