Evidence map›Paper›PMID 33221750›Full record

ArticleAging2020

Cognitive frailty in relation to adverse health outcomes independent of multimorbidity: results from the China health and retirement longitudinal study.

Chen Chen, JuYoung Park, Chenkai Wu, QianLi Xue, George Agogo, Ling Han, Emiel O Hoogendijk, Zuyun Liu, Zunyou Wu

Abstract read
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Global Prevalence of Cognitive Frailty in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis.Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chen ChenNational Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
JuYoung ParkFlorida Atlantic University, Phyllis and Harvey Sandler School of Social Work, Boca Raton, FL 33431, USA.
Chenkai WuGlobal Health Research Center, Duke Kunshan University, Kunshan, Jiangsu, China.
QianLi XueDivision of Geriatric Medicine and Gerontology and Center on Aging and Health, Johns Hopkins Medical Institute, Baltimore, MD 21224, USA.
George AgogoCenters for Disease Control and Prevention (CDC), Village Market, Nairobi, Kenya.
Ling HanDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Emiel O HoogendijkDepartment of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam UMC-location VU University Medical Center, Amsterdam, Netherlands.
Zuyun LiuDepartment of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA.
Zunyou WuNational Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.

Funding

China Health and Retirement Longitudinal StudyR01AG037031 · NIA · PEKING UNIVERSITY · PI STRAUSS, JOHN A, WANG, YAFENG · 2010 to 2024
$15.1M
Biomarkers in the China Health and Retirement Longitudinal StudyR21AG033675 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CRIMMINS, EILEEN M, STRAUSS, JOHN A · 2009 to 2010
$369k
China Health and Retirement Longitudinal Study - PilotR21AG031372 · NIA · PEKING UNIVERSITY · PI ZHAO, YAOHUI · 2007 to 2008
$273k
NIA NIH HHS R01 AG037031NIA NIH HHS R21 AG031372NIA NIH HHS R21 AG033675
6 · The paper itself

Abstract

Our objectives were to evaluate: 1) the associations of cognitive frailty with various health outcomes including disability, hospitalization, and death; 2) whether the associations differed by multimorbidity. We included data of 5113 Chinese older adults (aged 60+ years) who had baseline cognition and physical frailty assessments (2011 wave) and follow-up for 4 years. About 16.0% (n=820) had cognitive impairment; 6.7% (n=342) had physical frailty; and 1.6% (n=82) met criteria for cognitive frailty. Both cognitive impairment (odds ratios (ORs) range: 1.41 to 2.11) and physical frailty (ORs range: 1.51 to 2.43) were independently associated with basic activities of daily living (BADL), instrumental ADL (IADL), mobility disability, hospitalization, and death among participants without that corresponding outcome at baseline, even after accounting for covariates. Relative to participants who had normal cognition and were nonfrail, those with cognitive frailty had the highest risk for IADL disability (OR=3.40, 95% CI, 1.23-9.40) and death (OR=3.89, 95% CI, 2.25-6.47). We did not find significant interaction effects between cognitive frailty and multimorbidity (P

Indexed as

CognitionActivities of Daily LivingAgedAged, 80 and overAge FactorsChinaCognitive AgingCognitive DysfunctionDisability EvaluationFemaleFrail ElderlyFrailtyFunctional StatusHealth SurveysHospitalizationHumanscognitive frailtydeathdisabilitymultimorbidityolder adults

Identifiers

PMID33221750
PMCPMC7746379

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.