Evidence map›Paper›PMID 33221747›Full record

ArticleAging2020

Identification and characterization of dynamically regulated hepatitis-related genes in a concanavalin A-induced liver injury model.

Anna Chen, Yidong Wang, Jiaqi Wu, Dong Tang, Qianru Zhu, Anqian Lu, Jin Yang, Zhejun Cai, Junping Shi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Anna ChenTranslational Medicine Center, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Yidong WangDepartment of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Jiaqi WuTranslational Medicine Center, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Dong TangDepartment of Radiology, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Qianru ZhuTranslational Medicine Center, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Anqian LuTranslational Medicine Center, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Jin YangTranslational Medicine Center, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Zhejun CaiDepartment of Cardiology, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China.
Junping ShiTranslational Medicine Center, The Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China.
Affiliated Hospital of Hangzhou Normal University · CNSecond Affiliated Hospital of Zhejiang University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundConcanavalin A (ConA)-induced liver damage of mice is a well-established murine model mimicking the human autoimmune hepatitis (AIH). However, the pathogenic genes of the liver injury remain to be revealed.

methodsUsing time-series liver transcriptome, top dynamic genes were inferred from a set of segmented regression models, and cross-checked by weighted correlation network analysis (WGCNA). AIH murine models created by ConA were used to verify the

resultsWe identified 115 top dynamic genes, of which most were overlapped with the hub genes determined by WGCNA. The expression of several top dynamic genes including

conclusionWe have identified the top dynamic genes related to the process of acute liver injury, and highlighted a targeted strategy for

Indexed as

Concanavalin ATranscriptomeAnimalsChemical and Drug Induced Liver InjuryDatabases, GeneticDisease Models, AnimalGene Expression ProfilingGene Regulatory NetworksLiverMaleMice, Inbred C57BLTetraspanin 30Time FactorsCd63 protein, mouseConcanavalin ATetraspanin 30autoimmune hepatitisCd63concanavalin Atranscriptome

Identifiers

PMID33221747
PMCPMC7746381
OpenAlexW3108324707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.