ArticleJournal of affective disorders2021
Bridging Anxiety and Depression: A Network Approach in Anxious Adolescents.
Article in Journal of affective disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Psychiatric difficulties in females with fragile X syndrome: a systematic review and meta-analyses.Frontiers in psychiatry · 2026Pooled it
- A network model of depressive and anxiety symptoms: a statistical evaluation.Molecular psychiatry · 2024Pooled it
- Executive Functioning in Pediatric Anxiety and Its Relationship to Selective Serotonin Reuptake Inhibitor Treatment Response: A Double-Blind, Placebo-Controlled Trial.Journal of child and adolescent psychopharmacology · 2022Trial
- Symptom Networks, Developmental Pathways, and Intervention Evidence for Co-occurring Anxiety and Depression in Children and Adolescents: A Scoping Review.Research on child and adolescent psychopathology · 2026Article
- Psychobiotic Effects of Postbiotics in Depression, Psychosis and Mania.Health promotion perspectives · 2026Review
- Simulating symptom-specific interventions linking depression and anxiety among civil aviation college students: a network analysis differentiated by perceived parental relationships.BMC psychology · 2026Article
- Examining varying number of intervention-modules and change in individual networks in young people remitted from depression or anxiety: Exploratory outcomes of the StayFine randomized clinical trial.Neuroscience applied · 2026Article
- Associations of somatic and internalising symptoms with school absences: a national survey from Finland.BMJ public health · 2026Article
- The panic-sadness bridge: a longitudinal study using undirected and directed network analyses of COVID-19-related anxiety and depression.BMC psychiatry · 2025Article
- The use of atypical antipsychotic medications in the treatment of children and adolescents with avoidant/restrictive food intake disorder.European child & adolescent psychiatry · 2025Article
- The comorbidity of anxiety and depression symptoms in obsessive-compulsive disorder: a network analysis.Frontiers in psychiatry · 2025Article
- The relationship between callous-unemotional traits and internalizing psychopathology in adolescent psychiatric inpatients: a network analysis.Child and adolescent psychiatry and mental health · 2024Article
- Assessing relinquishment of positivity as a central symptom bridging anxiety and depression.Journal of affective disorders · 2024Article
- Edge-centric connectome-genetic markers of bridging factor to comorbidity between depression and anxiety.Nature communications · 2024Article
- Network analysis of depressive and anxiety symptoms in older Chinese adults with diabetes mellitus.Frontiers in psychiatry · 2024Article
- The Comorbidity of Depression and Anxiety Symptoms in Tinnitus Sufferers: A Network Analysis.Brain sciences · 2023Article
- Prevalence, correlates, and network analysis of depression and its associated quality of life among ophthalmology nurses during the COVID-19 pandemic.Frontiers in psychology · 2023Article
- Congruency of multimodal data-driven personalization with shared decision-making for StayFine: individualized app-based relapse prevention for anxiety and depression in young people.Frontiers in psychiatry · 2023Article
- Symptom-level networks of youth- and parent-reported depression and anxiety in a transdiagnostic clinical sample.Depression and anxiety · 2022Article
- Network analysis of anxiety and depression in the functionally impaired elderly.Frontiers in public health · 2022Article
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Authors and funding
7 authors.
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Abstract
backgroundThe phenomenology and neurobiology of depressive symptoms in anxious youth is poorly understood.
methodsAssociation networks of anxiety and depressive symptoms were developed in adolescents with generalized anxiety disorder (GAD; N=52, mean age: 15.4±1.6 years) who had not yet developed major depressive disorder. Community analyses were used to create consensus clusters of depressive and anxiety symptoms and to identify "bridge" symptoms between the clusters. In a subset of this sample (n=39), correlations between cortical thickness and depressive symptom severity was examined.
resultsTen symptoms clustered into an anxious community, 5 clustered into a depressive community and 5 bridged the two communities: impaired schoolwork, excessive weeping, low self-esteem, disturbed appetite, and physical symptoms of depression. Patients with more depressive cluster burden had altered cortical thickness in prefrontal, inferior and medial parietal (e.g., precuneus, supramarginal) regions and had decreases in cortical thickness-age relationships in prefrontal, temporal and parietal cortices. LIMITATIONS: Data are cross-sectional and observational. Limited sample size precluded secondary analysis of comorbidities and demographics.
conclusionsIn youth with GAD, a sub-set of symptoms not directly related to anxiety bridge anxiety and depression. Youth with greater depressive cluster burden had altered cortical thickness in cortical structures within the default mode and central executive networks. These alternations in cortical thickness may represent a distinct neurostructural fingerprint in anxious youth with early depressive symptoms. Finally, youth with GAD and high depressive symptoms had reduced age-cortical thickness correlations. The emergence of depressive symptoms in early GAD and cortical development may have bidirectional, neurobiological relationships.
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